Cytochromes P450 (CYP) are a major source of variability in drug pharmacokinetics and
response. Of 57 putatively functional human CYPs only about a dozen enzymes, belonging …

CYP3A is an enzyme subfamily in the cytochrome P450 (CYP) superfamily and includes
isoforms CYP3A4, CYP3A5, CYP3A7, and CYP3A43. CYP3A enzymes are indiscriminate …

BACKGROUND Analgesia during pregnancy is often necessary. Due to their widespread
availability, many mothers opt to use over-the-counter (OTC) analgesics. Those analgesic …

The exposure of the skin to medical drugs, skin care products, cosmetics, and other
chemicals renders information on xenobiotic-metabolizing enzymes (XME) in the skin highly …

Highlights•Understanding human skin models encourages their use in xenobiotic
metabolism testing.•Skin models indicate relevant expression and activity of phase II …

As a result of technical advances in recombinant DNA technology and nucleotide
sequencing, entire genome sequences have become available in the past decade and offer …

The cytochrome P450 4F (CYP4F) subfamily has over the last few years come to be
recognized for its dual role in modulating the concentrations of eicosanoids during …

Various members of the cytochrome P450 (CYP) superfamily have the capacity of
metabolizing omega-6 and omega-3 polyunsaturated fatty acids (n-6 and n-3 PUFAs). In …

Abstract Cytochrome P450 2J2 (CYP2J2) is an enzyme mainly found in human extrahepatic
tissues, with predominant expression in the cardiovascular systems and lower levels in the …

In general, xenobiotic metabolizing enzymes (XMEs) are expressed in lower levels in the
extrahepatic tissues than in the liver, making the former less relevant for the clearance of …