Maternal-fetal cross-talk via the placenta: influence on offspring development and metabolism

AC Kramer, T Jansson, TL Bale, TL Powell - Development, 2023 - journals.biologists.com
Compelling epidemiological and animal experimental data demonstrate that
cardiometabolic and neuropsychiatric diseases originate in a suboptimal intrauterine …

Fetomaternal expression of glucose transporters (GLUTs)—biochemical, cellular and clinical aspects

R Sibiak, K Ozegowska, E Wender-Ozegowska… - Nutrients, 2022 - mdpi.com
Several types of specialized glucose transporters (GLUTs) provide constant glucose
transport from the maternal circulation to the developing fetus through the placental barrier …

Glycolysis: A fork in the path of normal and pathological pregnancy

R Gou, X Zhang - The FASEB Journal, 2023 - Wiley Online Library
Glucose metabolism is vital to the survival of living organisms. Since the discovery of the
Warburg effect in the 1920s, glycolysis has become a major research area in the field of …

Differential expression of glucose transporter proteins GLUT-1, GLUT-3, GLUT-8 and GLUT-12 in the placenta of macrosomic, small-for-gestational-age and growth …

PJ Stanirowski, D Szukiewicz, A Majewska… - Journal of Clinical …, 2021 - mdpi.com
Placental transfer of glucose constitutes one of the major determinants of the intrauterine
foetal growth. The objective of the present study was to evaluate the expression of glucose …

Synthesis, characterization, crystallographic, binding, in silico and antidiabetic studies of novel 2, 4-thiazolidinedione-phenothiazine molecular hybrids

MA Doddagaddavalli, VKA Kalalbandi… - Journal of Molecular …, 2023 - Elsevier
thiazolidinedione-phenothiazine molecular hybrids, 9a–9t were synthesized, characterized
and screened for antidiabetic activities viz., α-amylase inhibition and glucose uptake assay …

METTL3 regulates glucose transporter expression in placenta exposed to hyperglycemia through the mTOR signaling pathway

J Ning, J Huai, S Wang, J Yan, R Su, M Zhang… - Chinese Medical …, 2024 - mednexus.org
Background: Alterations in the placental expression of glucose transporters (GLUTs), the
crucial maternal-fetal nutrient transporters, have been found in women with hyperglycemia …

Maternal diet during pregnancy and adaptive changes in the maternal and fetal pancreas have implications for future metabolic health

DJ Hill, TG Hill - Frontiers in Endocrinology, 2024 - frontiersin.org
Fetal and neonatal development is a critical period for the establishment of the future
metabolic health and disease risk of an individual. Both maternal undernutrition and …

[HTML][HTML] Adiponectin and Leptin during Pregnancy: A Systematic Review of Their Association with Pregnancy Disorders, Fetal Growth and Placental Function

T Downs, F da Silva Costa, C de Freitas Paganoti… - Endocrines, 2024 - mdpi.com
During pregnancy, the adipokines leptin and adiponectin can affect placental nutrient
transport and inflammatory pathways, potentially leading to altered fetal growth and …

Glucose uptake in trophoblasts of GDM mice is regulated by the AMPK-CLUT3 signaling pathway

Z Xiao, X Liu, X Luan, R Duan, W Peng, C Tong… - Scientific Reports, 2024 - nature.com
GDM, as a metabolic disease during pregnancy, regulates GLUT3 translocation by AMPK,
thereby affecting glucose uptake in trophoblasts. It provides a new research idea and …

Hyperglycemia in pregnancy-associated oxidative stress augments altered placental glucose transporter 1 trafficking via AMPKα/p38MAPK Signaling Cascade

S Wang, J Ning, J Huai, H Yang - International Journal of Molecular …, 2022 - mdpi.com
GLUT1, being a ubiquitous transporter isoform, is considered primarily responsible for
glucose uptake during glycolysis. However, there is still uncertainty about the regulatory …