Antiviral lectins: Selective inhibitors of viral entry

CA Mitchell, K Ramessar, BR O'Keefe - Antiviral research, 2017 - Elsevier
Many natural lectins have been reported to have antiviral activity. As some of these have
been put forward as potential development candidates for preventing or treating viral …

Griffithsin, a highly potent broad-spectrum antiviral lectin from red algae: From discovery to clinical application

C Lee - Marine drugs, 2019 - mdpi.com
Virus entry into a susceptible host cell is the first step in the formation of all viral diseases.
Controlling viral infections by disrupting viral entry is advantageous for antibody-mediated …

Griffithsin: an antiviral lectin with outstanding therapeutic potential

S Lusvarghi, CA Bewley - Viruses, 2016 - mdpi.com
Griffithsin (GRFT), an algae-derived lectin, is one of the most potent viral entry inhibitors
discovered to date. It is currently being developed as a microbicide with broad-spectrum …

The potential of algal biotechnology to produce antiviral compounds and biopharmaceuticals

S Rosales-Mendoza, I García-Silva… - Molecules, 2020 - mdpi.com
The emergence of the Coronavirus Disease 2019 (COVID-19) caused by the SARS-CoV-2
virus has led to an unprecedented pandemic, which demands urgent development of …

Griffithsin has antiviral activity against hepatitis C virus

P Meuleman, A Albecka, S Belouzard… - Antimicrobial agents …, 2011 - Am Soc Microbiol
Hepatitis C virus (HCV)-infected patients undergoing liver transplantation universally
experience rapid reinfection of their new liver graft. Current treatment protocols do not …

Lectins with anti-HIV activity: a review

O Akkouh, TB Ng, SS Singh, C Yin, X Dan, YS Chan… - Molecules, 2015 - mdpi.com
Lectins including flowering plant lectins, algal lectins, cyanobacterial lectins, actinomycete
lectin, worm lectins, and the nonpeptidic lectin mimics pradimicins and benanomicins …

Antiviral Lectins from Red and Blue-Green Algae Show Potent In Vitro and In Vivo Activity against Hepatitis C Virus

Y Takebe, CJ Saucedo, G Lund, R Uenishi, S Hase… - PLoS one, 2013 - journals.plos.org
Hepatitis C virus (HCV) infection is a significant public health problem with over 170,000,000
chronic carriers and infection rates increasing worldwide. Chronic HCV infection is one of …

Antiviral strategies using natural source-derived sulfated polysaccharides in the light of the COVID-19 pandemic and major human pathogenic viruses

B Ray, I Ali, S Jana, S Mukherjee, S Pal, S Ray… - Viruses, 2021 - mdpi.com
Only a mere fraction of the huge variety of human pathogenic viruses can be targeted by the
currently available spectrum of antiviral drugs. The severe acute respiratory syndrome …

Activity of and effect of subcutaneous treatment with the broad-spectrum antiviral lectin griffithsin in two laboratory rodent models

C Barton, JC Kouokam, AB Lasnik… - Antimicrobial agents …, 2014 - Am Soc Microbiol
Griffithsin (GRFT) is a red-alga-derived lectin that binds the terminal mannose residues of N-
linked glycans found on the surface of human immunodeficiency virus type 1 (HIV-1), HIV-2 …

Lectins from red algae and their biomedical potential

RS Singh, AK Walia - Journal of applied phycology, 2018 - Springer
Lectins are unique proteins or glycoproteins of non-immune origin that bind specifically to
carbohydrates. They recognise and interact reversibly to either free carbohydrates or …