Constitutional epimutation, which is an aberration in gene expression due to an altered
epigenotype that is widely distributed in normal tissues (albeit frequently mosaic), provides …

Skin, the largest organ of human body, is vital for the existence and survival of human
beings. Further, developmental and physiological mechanisms associated with cutaneous …

Epigenetic alterations are increasingly implicated in metastasis, whereas very few genetic
mutations have been identified as authentic drivers of cancer metastasis. Yet, to date, few …

Malignant melanoma is one of the most highly ranked cancers in terms of years of life lost.
Hereditary melanoma with its increased familial susceptibility is thought to affect up to 12 …

Cadmium is a highly toxic heavy metal, which has a destroying impact on organs. Exposure
to cadmium causes severe health problems to human beings due to its ubiquitous …

Importance Constitutional hypermethylation of 1 allele throughout the soma (constitutional
epimutation) is an accepted mechanism of cancer predisposition. Understanding the origin …

The aberrant DNA methylation plays a critical role in a number of different malignancies,
including melanoma. DNA methylation is catalyzed by DNA methyltransferases (DNMTs) …

Background: Melanoma has a complex molecular background and multiple genes are
involved in its development and progression. The advent of next generation sequencing …

In melanoma development, oncogenic process is mediated by genetic and epigenetic
mutations, and few studies have so far explored the role of DNA methylation either as …

The inactivation of p16 INK4A and p14 ARF via promoter methylation has been investigated
in various cancers. However, the clinical effects of p16 INK4A and p14 ARF promoter …