Aging is driven by hallmarks fulfilling the following three premises:(1) their age-associated
manifestation,(2) the acceleration of aging by experimentally accentuating them, and (3) the …

The mechanical properties of the nucleus influence different cellular and nuclear functions
and have relevant implications for several human diseases. The nucleus protects genetic …

Preeclampsia (PE) is the leading cause of maternal and fetal mortality globally and may
trigger dementia later in life in mothers and their offspring. However, the etiological drivers …

Cell function relies on the spatiotemporal dynamics of metabolic reactions. In all
physiopathological processes of tissues, mechanical forces impact the structure and function …

Transposable elements (TEs) play key roles in crucial biological pathways. Therefore,
several tools enabling the quantification of their expression were recently developed …

Regulated cell death predominantly involves apoptosis, autophagy, and regulated necrosis.
It is vital that we understand how key regulatory signals can control the process of cell death …

Huntington's disease (HD) is an autosomal dominant disorder with progressive motor
dysfunction and cognitive decline. The disease is caused by a CAG repeat expansion in the …

Background Molecular characterisation of hepatocellular carcinoma (HCC) is central to the
development of novel therapeutic strategies for the disease. We have previously …

Protein phosphorylation is one of the most common mechanisms regulating cellular
signaling pathways, and many kinases and phosphatases are proven drug targets. Upon …

Background The nuclear lamina links the nuclear membrane to chromosomes and plays a
crucial role in regulating chromatin states and gene expression. However, current …