Abstract Knowledge of protein structure can be used to predict the phenotypic consequence
of a missense variant. Since structural coverage of the human proteome can be roughly …

INTRODUCTION Tumor genome sequencing has revealed that, beyond a few commonly
mutated genes, most mutations that affect cancer genomes are rare. To interpret these rare …

The use of proximity-dependent biotinylation assays coupled to mass spectrometry (PDB-
MS) has changed the field of protein–protein interaction studies. However, despite the …

Mutations in protein-coding regions underlie almost all Mendelian disorders, drive
tumorigenesis, and contribute to susceptibility to common diseases. Despite the great …

Mutations, which result in amino acid substitutions, influence the stability of proteins and
their binding to biomolecules. A molecular understanding of the effects of protein mutations …

Missense variants are present amongst the healthy population, but some of them are
causative of human diseases. A classification of variants associated with “healthy” or …

Protein–protein interactions (PPIs) are critical for organizing molecules in a cell and
mediating signaling pathways. Dysregulation of PPIs is often a key driver of disease. To …

Efficiently identifying the most important communities and key transition nodes in weighted
and unweighted networks is a prevalent problem in a wide range of disciplines. Here, we …

A disease has distinct genetic and molecular hallmarks such as sequence variants that are
likely to produce the alternative protein structures accountable for individual responses to …

Background. Asthma is a common chronic respiratory disease in children, seriously affecting
children's health and growth. This bioinformatics study aimed to identify potential RNA …