DNA-dependent protein kinase regulates lysosomal AMP-dependent protein kinase activation and autophagy

P Puustinen, A Keldsbo, E Corcelle-Termeau, K Ngoei… - Autophagy, 2020 - Taylor & Francis
Macroautophagy/autophagy is a central component of the cytoprotective cellular stress
response. To enlighten stress-induced autophagy signaling, we screened a human kinome …

Structure-function analysis of the AMPK activator SC4 and identification of a potent pan AMPK activator

AJ Ovens, YS Gee, NXY Ling, D Yu… - Biochemical …, 2022 - portlandpress.com
The AMP-activated protein kinase (AMPK) αβγ heterotrimer is a primary cellular energy
sensor and central regulator of energy homeostasis. Activating skeletal muscle AMPK with …

[PDF][PDF] QUE PARA OBTENER EL TITULO DE: BIÓLOGO

BDD PÉREZ - 2023 - ru.dgb.unam.mx
La autofagia es un proceso fisiológico conservado por la evolución, en el cual se realiza el
reciclaje de constituyentes celulares. La limitación de nutrientes o la supresión de factores …

DNA-PKcs-mediated phosphorylation of AMPKγ1 regulates lysosomal AMPK activation by LKB1

P Puustinen, A Keldsbo, E Corcelle-Termeau, K Ngoei… - bioRxiv, 2018 - biorxiv.org
Autophagy is a central component of the cytoprotective cellular stress response. To
enlighten stress-induced autophagy signaling, we screened a human kinome siRNA library …

Novel torin1-sensitive phosphorylation sites on the metabolic regulator AMPK revealed by label-free mass spectrometry

WJ Smiles, AJ Ovens, D Yu, NXY Ling, KR Morrison… - bioRxiv, 2021 - biorxiv.org
AMPK and mTORC1 are nutrient-sensitive protein kinases that form a fundamental negative
feedback loop that governs cell growth and proliferation. AMPK is an αβγ heterotrimer that is …