The role of the reactive oxygen species and oxidative stress in the pathomechanism of the age‐related ocular diseases and other pathologies of the anterior and …

M Nita, A Grzybowski - Oxidative medicine and cellular …, 2016 - Wiley Online Library
The reactive oxygen species (ROS) form under normal physiological conditions and may
have both beneficial and harmful role. We search the literature and current knowledge in the …

Oxidative stress and antioxidants in age-related macular degeneration

N Kushwah, K Bora, M Maurya, MC Pavlovich, J Chen - Antioxidants, 2023 - mdpi.com
Oxidative stress plays a crucial role in aging-related eye diseases, including age-related
macular degeneration (AMD), cataracts, and glaucoma. With age, antioxidant reparative …

Injectable anti‐inflammatory supramolecular nanofiber hydrogel to promote anti‐VEGF therapy in age‐related macular degeneration treatment

H Gao, M Chen, Y Liu, D Zhang, J Shen… - Advanced …, 2023 - Wiley Online Library
Age‐related macular degeneration (AMD) is a major cause of visual impairment and severe
vision loss worldwide, while the currently available treatments are often unsatisfactory …

Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD

SK Mitter, C Song, X Qi, H Mao, H Rao, D Akin… - Autophagy, 2014 - Taylor & Francis
Autophagic dysregulation has been suggested in a broad range of neurodegenerative
diseases including age-related macular degeneration (AMD). To test whether the autophagy …

Age-related macular degeneration: role of oxidative stress and blood vessels

Y Ruan, S Jiang, A Gericke - International journal of molecular sciences, 2021 - mdpi.com
Age-related macular degeneration (AMD) is a common irreversible ocular disease
characterized by vision impairment among older people. Many risk factors are related to …

Consequences of oxidative stress in age-related macular degeneration

SG Jarrett, ME Boulton - Molecular aspects of medicine, 2012 - Elsevier
The retina resides in an environment that is primed for the generation of reactive oxygen
species (ROS) and resultant oxidative damage. The retina is one of the highest oxygen …

Retina in a dish: Cell cultures, retinal explants and animal models for common diseases of the retina

S Schnichels, F Paquet-Durand, M Löscher… - Progress in retinal and …, 2021 - Elsevier
For many retinal diseases, including age-related macular degeneration (AMD), glaucoma,
and diabetic retinopathy (DR), the exact pathogenesis is still unclear. Moreover, the currently …

Central role of oxidative stress in age‐related macular degeneration: evidence from a review of the molecular mechanisms and animal models

S Abokyi, CH To, TT Lam, DY Tse - Oxidative medicine and …, 2020 - Wiley Online Library
Age‐related macular degeneration (AMD) is a common cause of visual impairment in the
elderly. There are very limited therapeutic options for AMD with the predominant therapies …

Animal models of age related macular degeneration

ME Pennesi, M Neuringer, RJ Courtney - Molecular aspects of medicine, 2012 - Elsevier
Age related macular degeneration (AMD) is the leading cause of vision loss of those over
the age of 65 in the industrialized world. The prevalence and need to develop effective …

The impact of oxidative stress on blood-retinal barrier physiology in age-related macular degeneration

A Tisi, M Feligioni, M Passacantando, M Ciancaglini… - Cells, 2021 - mdpi.com
The blood retinal barrier (BRB) is a fundamental eye component, whose function is to select
the flow of molecules from the blood to the retina and vice-versa, and its integrity allows the …