The role of CDK5 in tumours and tumour microenvironments
Simple Summary CDK5 is a serine/threonine type kinase that is mainly found in nerves. It is
a target that has been studied primarily in neurological disorders, but recently it has been …
a target that has been studied primarily in neurological disorders, but recently it has been …
Interplay between MEK-ERK signaling, cyclin D1, and cyclin-dependent kinase 5 regulates cell cycle reentry and apoptosis of neurons
In response to neurotoxic signals, postmitotic neurons make attempts to reenter the cell
cycle, which results in their death. Although several cell cycle proteins have been implicated …
cycle, which results in their death. Although several cell cycle proteins have been implicated …
Differences in activity and phosphorylation of MAPK enzymes in esophageal squamous cells of GERD patients with and without Barrett's esophagus
HY Zhang, X Zhang, X Chen… - American Journal …, 2008 - journals.physiology.org
We hypothesized that, in esophageal squamous epithelial cells, there are differences
among individuals in the signal transduction pathways activated by acid reflux that might …
among individuals in the signal transduction pathways activated by acid reflux that might …
Direct effects of HIV-1 Tat on excitability and survival of primary dorsal root ganglion neurons: possible contribution to HIV-1-associated pain
X Chi, T Amet, D Byrd, KH Chang, K Shah, N Hu… - PloS one, 2011 - journals.plos.org
The vast majority of people living with human immunodeficiency virus type 1 (HIV-1) have
pain syndrome, which has a significant impact on their quality of life. The underlying causes …
pain syndrome, which has a significant impact on their quality of life. The underlying causes …
Nestin serves as a prosurvival determinant that is linked to the cytoprotective effect of epidermal growth factor in rat vascular smooth muscle cells
YL Huang, CM Wu, GY Shi, GCC Wu… - Journal of …, 2009 - academic.oup.com
Nestin is an intermediate filament protein mainly expressed in muscle and neural
progenitors. Recently, we reported that nestin is expressed in rat vascular smooth muscle …
progenitors. Recently, we reported that nestin is expressed in rat vascular smooth muscle …
Cell cycle regulatory protein 5 (Cdk5) is a novel downstream target of ERK in carboplatin induced death of breast cancer cells (supplementary data)
Neuronal cell specific cyclin-dependent kinase 5 (Cdk5) is a known regulator of
neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. We report that …
neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. We report that …
Regulation of ERK kinase by MEK1 kinase inhibition in the brain
Metabotropic (slow) and ionotropic (fast) neurotransmission are integrated by intracellular
signal transduction mechanisms involving protein phosphorylation/dephosphorylation to …
signal transduction mechanisms involving protein phosphorylation/dephosphorylation to …
Protective effect of Homer 1a on tumor necrosis factor-α with cycloheximide-induced apoptosis is mediated by mitogen-activated protein kinase pathways
Although Homer 1, of the postsynaptic density, regulates apoptosis, the signaling
mechanisms are not fully elucidated. In this study, we found that tumor necrosis factor-α …
mechanisms are not fully elucidated. In this study, we found that tumor necrosis factor-α …
RNAi screening in primary human hepatocytes of genes implicated in genome-wide association studies for roles in type 2 diabetes identifies roles for CAMK1D and …
S Haney, J Zhao, S Tiwari, K Eng, LT Guey, E Tien - PloS one, 2013 - journals.plos.org
Genome-wide association (GWA) studies have described a large number of new candidate
genes that contribute to of Type 2 Diabetes (T2D). In some cases, small clusters of genes …
genes that contribute to of Type 2 Diabetes (T2D). In some cases, small clusters of genes …
MAPK/ERK1/2 signaling mediates endothelial-like differentiation of immature DCs in the microenvironment of esophageal squamous cell carcinoma
J Lu, J Zhao, K Liu, J Zhao, H Yang, Y Huang… - Cellular and molecular …, 2010 - Springer
Endothelial-like differentiation of dendritic cells (DCs) is a new phenomenon, and the
mechanism is still elusive. Here, we show that the tumor microenvironment derived from the …
mechanism is still elusive. Here, we show that the tumor microenvironment derived from the …