Background: Dapsone (4, 4'-diamino-diphenyl sulfone) is a synthetic derivative of sulfones,
with the antimicrobial activity described since 1937. It is also a drug traditionally used in …

Renal transplantation (RT) is the preferred treatment for end-stage renal disease. However,
clinical challenges persist, ie, early detection of graft dysfunction, timely identification of …

Hypothermic oxygenated machine perfusion (HOPE) was recently tested in preclinical trials
in kidney transplantation (KT). Here we investigate the effects of HOPE on extended-criteria …

Ischemia is a pathological process in which blood supply to a particular organ is temporarily
interrupted resulting in disturbed biological function and homeostasis of local tissues …

Background: Acute kidney injury (AKI) is a common and serious complication following
cardiac surgery. Dexmedetomidine, a highly selective α2-adrenergic agonist, has shown …

Kidney transplants from aged donors are more vulnerable to ischemic injury, suffer more
from delayed graft function and have a lower graft survival compared to kidneys from …

Ischemia–reperfusion injury is a key clinical problem of transplantology. Current
achievements in optimizing organ rinse solutions and storage techniques have significantly …

Purpose: This study aimed to analyze our data on delayed graft function (DGF) and to
identify associated factors. Methods: This is a retrospective case-control study of all patients …

The kidney epithelium, with its intricate arrangement of highly specialized cell types,
constitutes the functional core of the organ. Loss of kidney epithelium is linked to the loss of …

Abstract c-Myc plays an important role in cell proliferation, differentiation, and cell apoptosis.
FasL/Fas pathway is a key regulator of cell apoptosis. This study was aimed to investigate …