Sepsis is characterized as an uncontrolled host response to infection, and it represents a
serious health challenge, causing excess mortality and morbidity worldwide. The discovery …

In this article, we review the current evidence for the cellular and molecular mechanisms of
AKI, focusing on epithelial cell pathobiology and related cell-cell interactions, using ischemic …

Background The acute respiratory distress syndrome (ARDS) is characterized by disruption
of the alveolar-capillary barrier resulting in accumulation of proteinaceous edema and …

We tested the hypothesis that combined xenogenic (from mini-pig) adipose-derived
mesenchymal stem cell (ADMSC) and ADMSC-derived exosome therapy could reduce brain …

Microvascular dysfunction leads to multi-organ failure and mortality in sepsis. Our previous
studies demonstrated that administration of exogenous endothelial progenitor cells (EPCs) …

CD34 is a cell surface antigen expressed in numerous stem/progenitor cells including
hematopoietic stem cells (HSCs) and endothelial progenitor cells (EPCs), which are known …

The pivotal pathogenetic role of microRNAs (miRs) in sepsis-induced acute kidney injury
(AKI) has been demonstrated in mounting evidence. The functions of the target cells are …

Background Sepsis coincides with altered gene expression in different tissues.
Accumulating evidence has suggested that microRNAs, long non-coding RNAs, and circular …

Background Exosomes isolated from plasma of patients with sepsis may induce vascular
apoptosis and myocardial dysfunction by mechanisms related to inflammation and oxidative …

Extensive injury of endothelial cells in blood vasculature, especially in the microcirculatory
system, frequently occurs in hosts suffering from sepsis and the accompanied systemic …