The process of aging results in a host of changes at the cellular and molecular levels, which include senescence, telomere shortening, and changes in gene expression. Epigenetic …
Epigenetic modifications, including DNA methylation, represent a potential mechanism for environmental impacts on human disease. Maternal smoking in pregnancy remains an …
G Banderali, A Martelli, M Landi, F Moretti… - Journal of translational …, 2015 - Springer
A great deal of attention has been focused on adverse effects of tobacco smoking on conception, pregnancy, fetal, and child health. The aim of this paper is to discuss the current …
Derived from the term exposure, the exposome is an omic-scale characterization of the nongenetic drivers of health and disease. With the genome, it defines the phenome of an …
Maternal smoking during pregnancy has been found to influence newborn DNA methylation in genes involved in fundamental developmental processes. It is pertinent to understand the …
Developmental periods such as gestation and adolescence have enhanced plasticity leaving the brain vulnerable to harmful effects from nicotine use. Proper brain maturation …
CV Breton, CJ Marsit, E Faustman… - Environmental …, 2017 - ehp.niehs.nih.gov
Background: Characterization of the epigenome is a primary interest for children's environmental health researchers studying the environmental influences on human …
CL Relton, T Gaunt, W McArdle, K Ho… - International journal …, 2015 - academic.oup.com
ARIES is a population-based resource of DNA methylation data accessible by the research community, established with the aim of improving our understanding of the determinants and …
Environmental exposures during early life play a critical role in life-course health, yet the molecular phenotypes underlying environmental effects on health are poorly understood. In …