Abstract Organs-on-chips (OoCs), also known as microphysiological systems or 'tissue
chips'(the terms are synonymous), have attracted substantial interest in recent years owing …

Microphysiological systems (MPS, also known as “organ-on-a-chip”,“body-on-a-chip”, or
“human-on-a-chip”) have emerged over the last 15 years as attractive systems to probe …

We describe a human “Body‐on‐a‐chip” device (or microphysiological system) that could be
used to emulate drug distribution, metabolism, and action in the body. It is based upon a …

A microfluidic device with 3-D hydrogel cell cultures has been developed to test the
cytotoxicity of anti-cancer drugs while reproducing multi-organ interactions. In this device, a …

This paper reports a multi-throughput multi-organ-on-a-chip system formed on a pneumatic
pressure-driven medium circulation platform with a microplate-sized format as a novel type …

Recent progress in cell culture and microfabrication technologies has contributed to the
development of cell‐based biosensors for the functional characterization and detection of …

Whole animal testing is an essential part in evaluating the toxicological and
pharmacological profiles of chemicals and pharmaceuticals, but these experiments are …

Prediction of human response to drugs or chemicals is difficult as a result of the complexity
of living organisms. We describe an in vitro model that can realistically and inexpensively …

Written by more than 400 subject experts representing diverse academic and applied
domains, this multidisciplinary resource surveys the vanguard of biomaterials and …

Various factors, including the phylogenetic distance between laboratory animals and
humans, the discrepancy between current in vitro systems and the human body, and the …