Epidemiological and clinical studies over the past two decades have provided strong
evidence that genetic elements interacting with environmental components can individually …

Mucoepidermoid carcinoma (MEC) represents 10-15% of salivary neoplasms. Due to their
low incidence, it is challenging to conduct clinical trials and develop treatment guidelines …

Introduction: Salivary gland carcinomas (SGC) are histologically diverse cancers and next-
generation sequencing (NGS) to identify key molecular targets is an important aspect in the …

Simple Summary Neurotrophins are a family of proteins known for regulating nervous
system development and neuronal survival and plasticity. These proteins act by activating …

1. Background Quality of life of patients with head and neck cancer (HNC) is notoriously
poor because of the greater prevalence of pain compared with other cancer types. 15, 42 …

Recent investigations revealed the relationship between chronic periodontitis,
Porphyromonas gingivalis and cancer. However, host genes that change in response to …

Objectives Perineural invasion (PNI) is a common histopathological finding in head and
neck squamous cell carcinoma (HNSCC). We aimed to explore the molecular mechanisms …

Objectives To evaluate the expression of brain‐derived neurotrophic factor (BDNF), its
tyrosine kinase receptor B (TrkB), and two downstream targets of this pathway, Akt and …

Background Circulating cytokines can represent non-invasive biomarkers to improve
prediction of clinical outcomes of cancer patients. Here, plasma levels of IL-8, CCL4 …

Prosaposin (PSAP), a potent neurotrophic factor, is found in neuronal and non-neuronal
tissues and various biological fluids. Neuropathological conditions often alter PSAP …