▪ Abstract Neurotransmitter release is mediated by exocytosis of synaptic vesicles at the
presynaptic active zone of nerve terminals. To support rapid and repeated rounds of release …

Rab proteins are best known for their essential roles in exocytic and endocytic membrane
trafficking, which encompass the constitutive and regulated secretory routes, endocytosis via …

Membrane traffic in eukaryotic cells involves transport of vesicles that bud from a donor
compartment and fuse with an acceptor compartment. Common principles of budding and …

Long-term potentiation (LTP) of synaptic strength, the most established cellular model of
information storage in the brain, is expressed by an increase in the number of postsynaptic …

Multivesicular bodies (MVBs) are membranous structures within 60–100 nm diameter
vesicles accumulate. MVBs are generated after invagination and pinching off of the …

Dendritic spines are micron-sized membrane protrusions receiving most excitatory synaptic
inputs in the mammalian brain. Spines form and grow during long-term potentiation (LTP) of …

Cells use secreted signals (eg chemokines and growth factors) and sophisticated vehicles
such as argosomes, cytonemes, tunneling nanotubes and exosomes to relay important …

Human Mental Retardation (MR) is a common and highly heterogeneous pediatric disorder
affecting around 3% of the general population; at least 215 X-linked MR (XLMR) conditions …

Cytotoxic T lymphocytes and natural killer cells exert their cytotoxic activity through the
polarized secretion of cytotoxic granules at the immunological synapse. Rab27a and …

Rab proteins are small GTPases that act as essential regulators of vesicular trafficking. 44
subfamilies are known in humans, performing specific sets of functions at distinct subcellular …