Gel/hydrogel‐based in situ biomaterial platforms for cancer postoperative treatment and recovery
Tumor surgical resection is the major strategy for cancer treatment. Meanwhile,
perioperative treatment especially the postoperative adjuvant anticancer strategies play …
perioperative treatment especially the postoperative adjuvant anticancer strategies play …
Rationally designed drug delivery systems for the local treatment of resected glioblastoma
Glioblastoma (GBM) is a particularly aggressive brain cancer associated with high
recurrence and poor prognosis. The standard of care, surgical resection followed by …
recurrence and poor prognosis. The standard of care, surgical resection followed by …
Immunostimulant hydrogel for the inhibition of malignant glioma relapse post-resection
J Zhang, C Chen, A Li, W Jing, P Sun, X Huang… - Nature …, 2021 - nature.com
Immunotherapies have revolutionized intervention strategies for many primary cancers, but
have not improved the outcomes of glioblastoma multiforme (GBM), which remains one of …
have not improved the outcomes of glioblastoma multiforme (GBM), which remains one of …
Self-assembling paclitaxel-mediated stimulation of tumor-associated macrophages for postoperative treatment of glioblastoma
The unique cancer-associated immunosuppression in brain, combined with a paucity of
infiltrating T cells, contributes to the low response rate and poor treatment outcomes of T cell …
infiltrating T cells, contributes to the low response rate and poor treatment outcomes of T cell …
Noncanonical amino acids for hypoxia-responsive peptide self-assembly and fluorescence
B Hu, N Song, Y Cao, M Li, X Liu, Z Zhou… - Journal of the …, 2021 - ACS Publications
Design of endogenous stimuli-responsive amino acids allows for precisely modulating
proteins or peptides under a biological microenvironment and thereby regulating their …
proteins or peptides under a biological microenvironment and thereby regulating their …
Supramolecular filament hydrogel as a universal immunomodulator carrier for immunotherapy combinations
A major challenge of cancer immunotherapy is to develop delivery strategies that can
effectively and safely augment the immune system's antitumor response. Here, we report on …
effectively and safely augment the immune system's antitumor response. Here, we report on …
Recent trends in the development of hydrogel therapeutics for the treatment of central nervous system disorders
Q Li, X Shao, X Dai, Q Guo, B Yuan, Y Liu… - NPG Asia …, 2022 - nature.com
The central nervous system (CNS) controls the acquisition and processing of peripheral
information to manage the behaviors of organisms. CNS disorders, including CNS injuries …
information to manage the behaviors of organisms. CNS disorders, including CNS injuries …
Supramolecular tubustecan hydrogel as chemotherapeutic carrier to improve tumor penetration and local treatment efficacy
Local chemotherapy is a clinically proven strategy in treating malignant brain tumors. Its
benefits, however, are largely limited by the rapid release and clearance of therapeutic …
benefits, however, are largely limited by the rapid release and clearance of therapeutic …
Constructing antiretroviral supramolecular polymers as Long-acting Injectables through rational Design of Drug Amphiphiles with alternating antiretroviral-based and …
One of the main challenges in the development of long-acting injectables for HIV treatment
is the limited duration of drug release, which results in the need for frequent dosing and …
is the limited duration of drug release, which results in the need for frequent dosing and …
Controlled drug delivery with nanoassemblies of redox-responsive prodrug and polyprodrug amphiphiles
Self-assembled nanostructures are highly promising for controlled delivery of therapeutic
and diagnostic agents. However, for conventional drug delivery nanosystems, there exist …
and diagnostic agents. However, for conventional drug delivery nanosystems, there exist …