Appropriate activation of coagulation requires a balance between procoagulant and
anticoagulant proteins in blood. Loss in this balance leads to hemorrhage and thrombosis. A …

Transthyretin (TTR) is a tetrameric protein transporting hormones in the plasma and brain,
which has many other activities that have not been fully acknowledged. TTR is a positive …

Abstract C1 inhibitor (C1INH) is a multifunctional serine protease inhibitor that functions as a
major negative regulator of several biological pathways, including the contact pathway of …

Venous thromboembolism (VTE) is a common, multi-causal disease with potentially serious
short-and long-term complications. In clinical practice, there is a need for improved plasma …

We conducted cohort and Mendelian randomisation (MR) analyses to examine the
associations of circulating proteins with risk of venous thromboembolism (VTE) to provide …

Transthyretin amyloidosis (ATTR) is a group of diseases caused by the deposition of
insoluble fibrils derived from misfolded transthyretin, which compromises the structure and …

Abstract Background C1-inhibitor (C1INH) is a broad-acting serine protease inhibitor with
anticoagulant activity. The impact of C1INH plasma levels within the normal physiological …

The superfamily of serine protease inhibitors (SERPINs) are a class of inhibitors that utilise a
dynamic conformational change to trap and inhibit their target enzymes. Their powerful …

Understanding the genetic basis of neuro-related proteins is essential for dissecting the
molecular basis of human behavioural traits and the disease aetiology of neuropsychiatric …

Proteomics, the simultaneous study of all proteins in a given cell, tissue or organism, is an
innovative approach used to identify novel markers for diagnosis, prognosis and the …