Mathematical modeling has proved to be a critically important approach in the study of many
complex networks and dynamic systems in physics, engineering, chemistry, and biology …

Abstract Background The NF-κB and IRF transcription factor families are major players in
inflammation and antiviral response and act as two major effectors of the innate immune …

Mucosal surfaces of the human body are lined by a contiguous epithelial cell surface that
forms a barrier to aerosolized pathogens. Specialized pattern recognition receptors detect …

Toll-like receptors (TLRs) recognize specific pathogen–associated molecular patterns and
initiate innate immune responses through signaling pathways that depend on the adaptor …

Although a great deal is known about the signaling events that promote nuclear
translocation of NF‐κB, how cellular biophysics and the microenvironment might regulate …

The airway mucosa expresses protective interferon (IFN) and inflammatory cytokines in
response to respiratory syncytial virus (RSV) infection. In this study, we examine the role of …

Macrophage-initiated inflammation is tightly regulated to eliminate threats such as infections
while suppressing harmful immune activation. However, individual cells' signaling …

Lower respiratory tract infections from respiratory syncytial virus (RSV) are due, in part, to
secreted signals from lower airway cells that modify the immune response and trigger airway …

Respiratory syncytial virus (RSV) is a negative-sense single-stranded RNA virus responsible
for lower respiratory tract infections (LRTIs) in humans. In experimental models of RSV LRTI …

The epithelial-mesenchymal transition (EMT) is a multistep dedifferentiation program
important in tissue repair. Here, we examined the role of the transcriptional regulator NF-κB …