Management of paediatric extracranial germ-cell tumours carries a unique set of challenges.
Germ-cell tumours are a heterogeneous group of neoplasms that present across a wide age …

Germ cell tumors (GCTs) arising in infants, children, and adolescents present a set of special
challenges. GCTs make up about 3% of malignancies in children aged 0–18 and nearly …

Despite their extensive clinical and pathologic heterogeneity, all malignant germ cell tumors
(GCT) are thought to originate from primordial germ cells. However, no common biological …

During the past 35 years, survival rates for children with extracranial malignant germ cell
tumors (GCTs) have increased significantly. Success has been achieved primarily through …

This review focuses on the molecular characteristics and development of rare malignant
ovarian germ cell tumors (mOGCTs). We provide an overview of the genomic aberrations …

Although gain of chromosome 5p is one of the most frequent DNA copy‐number imbalances
in cervical squamous cell carcinoma (SCC), the genes that drive its selection remain poorly …

Background Testicular cancer is the most common cancer in young men in developed
countries. In adults, international variation in testicular cancer incidence rates has been well …

Purpose To compare the outcomes of paediatric and adolescent extracranial malignant
germ cell tumour (GCT) patients treated with either carboplatin or cisplatin on clinical trials …

Germ-cell tumors (GCTs), which arise from pluripotent embryonic germ cells, exhibit a wide
range of histologic differentiation states with varying clinical behaviors. Although testicular …

Simple Summary Because ovarian germ cell tumors (OGCTs) are rare tumors, our current
understanding of them is sparse; this is because few studies have investigated the …