Polo-like kinase 1 (PLK1) is the principle member of the well conserved serine/threonine
kinase family. PLK1 has a key role in the progression of mitosis and recent evidence …

The serine/threonine protein phosphatase (PP2A) is a trimeric holoenzyme that plays an
integral role in the regulation of a number of major signaling pathways whose deregulation …

Polo-like kinases (Plk) function in mitosis and maintaining DNA integrity. There are four
family members, of which Plk1 represents a target for anticancer therapy. Plk1 is only …

Cells are constantly suffering genotoxic stresses that affect the integrity of our genetic
material. Genotoxic insults must be repaired to avoid the loss or inappropriate transmission …

The DNA of all organisms is constantly subjected to damaging agents, both exogenous and
endogenous. One extremely harmful lesion is the double-strand break (DSB), which …

Polo-like kinase 1 (Plk1) is a key regulator of cell division in eukaryotic cells. In this review
we focus on recent leaps in our understanding of how Plk1 controls cytokinesis, the final …

Abstract Polo-like kinase 1 (Plk1) is a well-established mitotic regulator with a diverse range
of biologic functions continually being identified throughout the cell cycle. Preclinical …

Abstract Polo‐like kinase 1 (Plk1) is a critical regulator of many stages of mitosis; increasing
evidence indicates that Plk1 overexpression correlates with poor clinical outcome, yet its …

Reversible phosphorylation plays a critical role in DNA repair. Here, we report the results of
a loss-of-function screen that identifies the PP2A heterotrimeric serine/threonine …

Cell cycle process is regulated by a number of protein kinases and among them,
serine/threonine kinases carry phosphate group from ATP to substrates. The most important …