Proteins adopt different higher-order structures (HOS) to enable their unique biological
functions. Understanding the complexities of protein higher-order structures and dynamics …

Hydroxyl radical protein footprinting (HRPF) coupled to mass spectrometry has been
successfully used to investigate a plethora of protein-related questions. The method, which …

Highlights•Intrinscially disordered proteins (IDPs) are abundant and involved in many
diseases.•Advances and challenges in drug design targeting IDPs are discussed.•Known …

Covalent labeling (CL) in combination with mass spectrometry can be used as an analytical
tool to study and determine structural properties of protein-protein complexes. However …

Knowledge of protein structure is paramount to the understanding of biological function,
developing new therapeutics, and making detailed mechanistic hypotheses. Therefore …

Using mass spectrometry (MS) to obtain information about a higher order structure of protein
requires that a protein's structural properties are encoded into the mass of that protein …

Long non-coding RNAs (lncRNAs) constitute a significant fraction of the transcriptome,
playing important roles in development and disease. However, our understanding of …

Structures of many complex biological assemblies are increasingly determined using
integrative approaches, in which data from multiple experimental methods are combined. A …

Structures of biomolecular systems are increasingly computed by integrative modeling. In
this approach, a structural model is constructed by combining information from multiple …

Intrinsically disordered proteins (IDPs) and regions of intrinsic disorder (IDRs) are abundant
in proteomes and are essential for many biological processes. Thus, they are often …