Versican—a critical extracellular matrix regulator of immunity and inflammation

TN Wight, I Kang, SP Evanko, IA Harten… - Frontiers in …, 2020 - frontiersin.org
The extracellular matrix (ECM) proteoglycan, versican increases along with other ECM
versican binding molecules such as hyaluronan, tumor necrosis factor stimulated gene-6 …

Signaling mechanisms regulating endothelial permeability

D Mehta, AB Malik - Physiological reviews, 2006 - journals.physiology.org
The microvascular endothelial cell monolayer localized at the critical interface between the
blood and vessel wall has the vital functions of regulating tissue fluid balance and supplying …

Concise review: bone marrow for the treatment of spinal cord injury: mechanisms and clinical applications

KT Wright, WE Masri, A Osman, J Chowdhury… - Stem …, 2011 - academic.oup.com
Transplantation of bone marrow stem cells into spinal cord lesions enhances axonal
regeneration and promotes functional recovery in animal studies. There are two types of …

The biological role and regulation of versican levels in cancer

C Ricciardelli, AJ Sakko, MP Ween, DL Russell… - Cancer and Metastasis …, 2009 - Springer
Increased expression of the proteoglycan, versican is strongly associated with poor outcome
for many different cancers. Depending on the cancer type, versican is expressed by either …

Pulmonary interstitial matrix and lung fluid balance from normal to the acutely injured lung

E Beretta, F Romanò, G Sancini, JB Grotberg… - Frontiers in …, 2021 - frontiersin.org
This review analyses the mechanisms by which lung fluid balance is strictly controlled in the
air-blood barrier (ABB). Relatively large trans-endothelial and trans-epithelial Starling …

Versican: a dynamic regulator of the extracellular matrix

S Islam, H Watanabe - Journal of Histochemistry & …, 2020 - journals.sagepub.com
Versican is a large chondroitin sulfate/dermatan sulfate proteoglycan belonging to the
aggrecan/lectican family. In adults, this proteoglycan serves as a structural macromolecule …

Proteolysis: a key post-translational modification regulating proteoglycans

TJ Mead, S Bhutada, DR Martin… - American Journal of …, 2022 - journals.physiology.org
Proteoglycans are composite molecules comprising a protein backbone, ie, the core protein,
with covalently attached glycosaminoglycan chains of distinct chemical types. Most …

Collagens, proteoglycans, MMP-2, MMP-9 and TIMPs in human achilles tendon rupture

E Karousou, M Ronga, D Vigetti, A Passi… - Clinical orthopaedics and …, 2008 - Springer
Tendon integrity depends on the extracellular matrix (ECM) metabolism which is regulated
by proteolytic enzymes. However, it is unclear which enzymes play a role in tendon rupture …

T and T2 mapping reveal the in vivo extracellular matrix of articular cartilage

H Nishioka, J Hirose, E Nakamura… - Journal of Magnetic …, 2012 - Wiley Online Library
Purpose: To determine the relationship between changes in the extracellular matrix (ECM)
and T1ρ and T2 values in vivo. The ECM is composed of proteoglycan (PG), collagen, and …

Accumulation of versican facilitates wound healing: implication of its initial ADAMTS-cleavage site

S Islam, K Chuensirikulchai, S Khummuang… - Matrix Biology, 2020 - Elsevier
Versican is a large chondroitin sulfate/dermatan sulfate proteoglycan in the extracellular
matrix, and is expressed at high levels in tissues during development and remodeling in …