Krüppel-like factor 4 (KLF4): What we currently know

AM Ghaleb, VW Yang - Gene, 2017 - Elsevier
Krüppel-like factor 4 (KLF4) is an evolutionarily conserved zinc finger-containing
transcription factor that regulates diverse cellular processes such as cell growth …

Recent discoveries on the involvement of Krüppel-like factor 4 in the most common cancer types

A Taracha-Wisniewska, G Kotarba, S Dworkin… - International Journal of …, 2020 - mdpi.com
Krüppel-like factor 4 (KLF4) is a transcription factor highly conserved in evolution. It is
particularly well known for its role in inducing pluripotent stem cells. In addition, KLF4 plays …

Epigenetic mechanisms regulate MHC and antigen processing molecules in human embryonic and induced pluripotent stem cells

B Suarez-Alvarez, RM Rodriguez, V Calvanese… - PloS one, 2010 - journals.plos.org
Background Human embryonic stem cells (hESCs) are an attractive resource for new
therapeutic approaches that involve tissue regeneration. hESCs have exhibited low …

Oocyte quality in lactating dairy cows fed on high levels of n-3 and n-6 fatty acids

AA Fouladi-Nashta, KE Wonnacott… - …, 2009 - rep.bioscientifica.com
Spermatogonial stem cells (SSCs) maintain spermatogenesis by self-renewal and
generation of spermatogonia committed to differentiation. Under certain in vitro conditions …

Transcription factors: Key regulatory targets of vascular smooth muscle cell in atherosclerosis

Y Jiang, HY Qian - Molecular Medicine, 2023 - Springer
Atherosclerosis (AS), leading to gradual occlusion of the arterial lumen, refers to the
accumulation of lipids and inflammatory debris in the arterial wall. Despite therapeutic …

[HTML][HTML] Bovid microRNAs involved in the process of spermatogonia differentiation into spermatocytes

C Xu, M ali Shah, TD Mipam, S Wu, C Yi… - … Journal of Biological …, 2020 - ncbi.nlm.nih.gov
The male infertility of cattleyak resulted from spermatogenic arrest has greatly restricted the
effective utilization of the heterosis from crossbreeding of cattle and yak. Based on our …

Follicle-stimulating hormone-mediated decline in miR-92a-3p expression in pubertal mice Sertoli cells is crucial for germ cell differentiation and fertility

A Gupta, A Vats, A Ghosal, K Mandal, R Sarkar… - Cellular and Molecular …, 2022 - Springer
Sertoli cells (Sc) are the sole target of follicle-stimulating hormone (FSH) in the testis and
attain functional maturation post-birth to significantly augment germ cell (Gc) division and …

[HTML][HTML] KLF8 promotes tumorigenesis, invasion and metastasis of colorectal cancer cells by transcriptional activation of FHL2

Q Yan, W Zhang, Y Wu, M Wu, M Zhang, X Shi, J Zhao… - Oncotarget, 2015 - ncbi.nlm.nih.gov
The transcription factor Krüppel-like factor (KLF) 8 plays an important role in the formation of
several human tumors, including colorectal cancer. We recently identified four-and-a-half …

MicroRNA‐10b regulates the renewal of spermatogonial stem cells through Kruppel‐like factor 4

J Li, X Liu, X Hu, GG Tian, W Ma, X Pei… - Cell Biochemistry …, 2017 - Wiley Online Library
MicroRNAs (miRs) are functionally important in spermatogenesis, which is the self‐renewal
or differentiation of spermatogonial stem cells (SSCs). Here, we report a novel role for miR …

[PDF][PDF] Krüppel-like factor 4 is widely expressed in the mouse male and female reproductive tract and responds as an immediate early gene to activation of the protein …

M Godmann, C Kosan, R Behr - Reproduction, 2010 - Citeseer
Krüppel-like factor 4 (KLF4) is a zinc finger transcription factor critically involved in cell
proliferation, differentiation, and carcinogenesis. Recently, KLF4 was also used for the …