Abstract Magnesium (Mg 2+) is an essential ion to the human body, playing an instrumental
role in supporting and sustaining health and life. As the second most abundant intracellular …

Calcium signaling underlies much of physiology. Almost all the Ca2+ in the cytoplasm is
bound to buffers, with typically only∼ 1% being freely ionized at resting levels in most cells …

The role of the kidney in calcium homeostasis has been reshaped from a classic view in
which the kidney was regulated by systemic calcitropic hormones such as vitamin D3 or …

Exercise benefits M2 macrophage polarization, energy homeostasis and protects against
obesity partially through exercise-induced circulating factors. Here, by unbiased quantitative …

Up to 90% of patients with castrate-resistant prostate cancer develop bone metastases, and
the majority of these men have received androgen deprivation therapy known to cause bone …

Magnesium is an essential cofactor in many cellular processes, and aberrations in
magnesium homeostasis can have life-threatening consequences. The kidney plays a …

Background Calcium is an essential macronutrient that is involved in many cellular
processes. Homeostatic control of intracellular levels of calcium ions [Ca 2+] is vital to …

New insights in regulation of calcium homeostasis : Current Opinion in Nephrology and
Hypertension New insights in regulation of calcium homeostasis : Current Opinion in …

Background In the last two decades, progress in cytogenetic and genome research has
enabled investigators to unravel the underlying molecular mechanisms of inherited …

The genetic disease Gitelman syndrome, knockout mice, and pharmacological blockade
with thiazide diuretics have revealed that reduced activity of the NaCl cotransporter (NCC) …