The concept of strain in organic compounds is as old as modern organic chemistry and was
initially introduced to justify the synthetic setbacks along the synthesis of small ring systems …

Benzenes, the most ubiquitous structural moiety in marketed small-molecule drugs, are
frequently associated with poor 'drug-like'properties, including metabolic instability, and poor …

We report the use of photocatalysis for the homolytic ring-opening of carbonyl
cyclopropanes. In contrast to previous studies, our approach does not require a metal …

Abstract Bicyclo [2.1. 1] hexanes (BCHs) are becoming ever more important in drug design
and development as bridged scaffolds that provide underexplored chemical space, but are …

Bicyclic amines are important motifs for the preparation of bioactive materials. These species
have well-defined exit vectors that enable accurate disposition of substituents toward …

Bridged or caged polycyclic hydrocarbons have rigid structures that project substituents into
precise regions of 3D space, making them attractive as linking groups in materials science …

Bicyclo [2.1. 1] hexanes have been synthesized, characterized, and biologically validated as
saturated bioisosteres of the ortho-substituted benzene ring. The incorporation of the 1, 2 …

Saturated bridged-bicyclic compounds are currently under intense investigation as building
blocks for pharmaceutical drug design. However, the most common methods for their …

Aryl amines are one of the most common moieties in biologically active molecules, and
approximately 37% of drug candidates contain aromatic amines. Recent advancements in …

Cuneane is a strained hydrocarbon that can be accessed via metal-catalyzed isomerization
of cubane. The carbon atoms of cuneane define a polyhedron of the C 2 v point group with …