Endoplasmic reticulum stress and lipids in health and diseases
The endoplasmic reticulum (ER) is a complex and dynamic organelle that regulates many
cellular pathways, including protein synthesis, protein quality control, and lipid synthesis …
cellular pathways, including protein synthesis, protein quality control, and lipid synthesis …
Formation and function of phosphatidylserine and phosphatidylethanolamine in mammalian cells
JE Vance, G Tasseva - Biochimica et Biophysica Acta (BBA)-Molecular and …, 2013 - Elsevier
Phosphatidylserine (PS) and phosphatidylethanolamine (PE) are metabolically related
membrane aminophospholipids. In mammalian cells, PS is required for targeting and …
membrane aminophospholipids. In mammalian cells, PS is required for targeting and …
Production of the antimalarial drug precursor artemisinic acid in engineered yeast
Malaria is a global health problem that threatens 300–500 million people and kills more than
one million people annually. Disease control is hampered by the occurrence of multi-drug …
one million people annually. Disease control is hampered by the occurrence of multi-drug …
HMG-CoA reductase inhibitors and the malignant cell: the statin family of drugs as triggers of tumor-specific apoptosis
The statin family of drugs target HMG-CoA reductase, the rate-limiting enzyme of the
mevalonate pathway, and have been used successfully in the treatment of …
mevalonate pathway, and have been used successfully in the treatment of …
Biosynthesis of plant isoprenoids: perspectives for microbial engineering
J Kirby, JD Keasling - Annual review of plant biology, 2009 - annualreviews.org
Isoprenoids are a large and highly diverse group of natural products with many functions in
plant primary and secondary metabolism. Isoprenoids are synthesized from common prenyl …
plant primary and secondary metabolism. Isoprenoids are synthesized from common prenyl …
Regulation of sterol synthesis in eukaryotes
PJ Espenshade, AL Hughes - Annu. Rev. Genet., 2007 - annualreviews.org
Cholesterol is an essential component of mammalian cell membranes and is required for
proper membrane permeability, fluidity, organelle identity, and protein function. Cells …
proper membrane permeability, fluidity, organelle identity, and protein function. Cells …
Microbial production of limonene and its derivatives: Achievements and perspectives
Y Ren, S Liu, G Jin, X Yang, YJ Zhou - Biotechnology Advances, 2020 - Elsevier
Limonene and its derivatives have great market potential with diverse applications in food,
pharmaceuticals, cosmetics, etc. Commercial production of limonene and its derivatives …
pharmaceuticals, cosmetics, etc. Commercial production of limonene and its derivatives …
PeakDecoder enables machine learning-based metabolite annotation and accurate profiling in multidimensional mass spectrometry measurements
Multidimensional measurements using state-of-the-art separations and mass spectrometry
provide advantages in untargeted metabolomics analyses for studying biological and …
provide advantages in untargeted metabolomics analyses for studying biological and …
Redirection of cytosolic or plastidic isoprenoid precursors elevates terpene production in plants
S Wu, M Schalk, A Clark, RB Miles, R Coates… - Nature …, 2006 - nature.com
Terpenes constitute a distinct class of natural products1 that attract insects, defend against
phytopathogenic microbes and combat human diseases. However, like most natural …
phytopathogenic microbes and combat human diseases. However, like most natural …
Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain
Sterols accelerate degradation of the ER enzyme 3-hydroxy-3-methylglutaryl CoA reductase
(HMG CoA reductase), which catalyzes a rate-controlling step in cholesterol biosynthesis …
(HMG CoA reductase), which catalyzes a rate-controlling step in cholesterol biosynthesis …