Recent data show that B cells and plasma cells located in tumours or in tumour-draining
lymph nodes can have important roles in shaping antitumour immune responses. In tumour …

The transmembrane glycoprotein Mucin 1 (MUC1) is aberrantly glycosylated and
overexpressed in a variety of epithelial cancers, and plays a crucial role in progression of …

During malignant transformation, glycosylation is heavily altered compared with healthy
tissue due to differential expression of glycosyltransferases, glycosidases and …

Breast cancer rises as the most commonly diagnosed cancer in 2020. Among women,
breast cancer ranks first in both cancer incidence rate and mortality. Treatment resistance …

Background The mucins found as components of mucus gel layers at mucosal surfaces
throughout the body play roles in protection as part of the defensive barrier on an organ and …

Glycosylation of proteins is one of the most important PTMs, with more than half of all human
proteins estimated to be glycosylated. It is widely known that aberrant glycosylation has …

Malignant transformation of cells is associated with aberrant glycosylation presented on the
cell-surface. Commonly observed changes in glycan structures during malignancy …

Antibody-derived chimeric antigen receptor (CAR) T cell therapy has achieved gratifying
breakthrough in hematologic malignancies but has shown limited success in solid tumor …

Aptamers are a special class of nucleic acid molecules that are beginning to be investigated
for clinical use. These small RNA/DNA molecules can form secondary and tertiary structures …

Mucin-type O-glycans are a class of glycans initiated with N-acetylgalactosamine (GalNAc) α-
linked primarily to Ser/Thr residues within glycoproteins and often extended or branched by …