Advanced multifunctional nano-lipid carrier loaded gel for targeted delivery of 5-flurouracil and cannabidiol against non-melanoma skin cancer

N Hasan, M Imran, A Sheikh, N Tiwari, A Jaimini… - Environmental …, 2023 - Elsevier
Non-melanoma skin cancer is one of the most common malignancies reported around the
globe. Current treatment therapies fail to meet the desired therapeutic efficacy due to high …

[HTML][HTML] Efficacy and safety of immunological adjuvants. Where is the cut-off?

A Batista-Duharte, DT Martínez, IZ Carlos - Biomedicine & …, 2018 - Elsevier
Research over the past several decades has provided insight into the mode of action of
adjuvants. However, the main focus of attention has been the efficacy in the induction of …

Targeted clindamycin delivery to pilosebaceous units by chitosan or hyaluronic acid nanoparticles for improved topical treatment of acne vulgaris

S Tolentino, MN Pereira, M Cunha-Filho, T Gratieri… - Carbohydrate …, 2021 - Elsevier
We developed chitosan or hyaluronic acid nanoparticles to entrap clindamycin and
evaluated for the first time the impact of these two polymeric nanosystems on the targeted …

[HTML][HTML] Insights into the cytotoxicity and irritant potential of chlorhexidine digluconate: an in vitro and in ovo safety screening

S Dinu, A Matichescu, R Buzatu, I Marcovici… - Dentistry Journal, 2024 - mdpi.com
Chlorhexidine (CHX) represents one of the most commonly used antiseptics in dentistry and
other medical–pharmaceutical fields due to its broad-spectrum antimicrobial activity …

Augmented efficiency of azithromycin for MRSA ocular infections management: Limonene-based nanostructured lipid carriers in-situ approach

KK Abla, SM Hijazi, MM Mehanna - Journal of Drug Delivery Science and …, 2023 - Elsevier
Staphylococcus aureus (S. aureus) is the main pathogen that leads to serious ocular
infectious disorders such as endophthalmitis and keratitis. A major obstacle in managing …

Rapidly dissolving bilayer microneedles enabling minimally invasive and efficient protein delivery to the posterior segment of the eye

Y Wu, LK Vora, RF Donnelly, TRR Singh - Drug Delivery and Translational …, 2023 - Springer
The discovery of proteins that neutralise vascular endothelial growth factors, such as
pegaptanib, ranibizumab and aflibercept, can inhibit the process of angiogenesis, thereby …

Controlled release, chitosan-tethered luteolin phytocubosomes; Formulation optimization to in-vivo antiglaucoma and anti-inflammatory ocular evaluation

S Omran, YSR Elnaggar, OY Abdallah - International Journal of Biological …, 2024 - Elsevier
A chitosan-coated luteolin-loaded phytocubosomal system was prepared to improve the
pharmacodynamic performance of luteolin in the treatment of glaucoma and ocular …

Eco-sustainable biorefinery to the management of winery waste by integrating sequential ready-to-use pigments and bioenergy through advanced multi-step kinetic …

CU Mussagy, LM de Souza Mesquita… - Industrial Crops and …, 2024 - Elsevier
This study aimed to design a sequential biorefinery from wine-making by-products for the
obtaining value-added products, focusing on extracting natural pigments and the evaluation …

High concentrations of aspartame induce pro-angiogenic effects in ovo and cytotoxic effects in HT-29 human colorectal carcinoma cells

AL Maghiari, D Coricovac, IA Pinzaru, IG Macașoi… - Nutrients, 2020 - mdpi.com
Aspartame (ASP), an artificial sweetener abundantly consumed in recent years in an array of
dietary products, has raised some concerns in terms of toxicity, and it was even suggested a …

[HTML][HTML] Pullulan film incorporated with nanocapsules improves pomegranate seed oil anti-inflammatory and antioxidant effects in the treatment of atopic dermatitis in …

VF Cervi, CP Saccol, MHM Sari, CC Martins… - International Journal of …, 2021 - Elsevier
This study aimed to prepare pullulan films containing pomegranate seeds oil (PSO) based
nanocapsules, and evaluate the formulation efficacy in the treatment of atopic dermatitis …