We review the transport, synthesis and catabolism of glutathione in the brain as well as its
compartmentation and biochemistry in different brain cells. The major reactions involving …

With millions of older individuals presently suffering from Alzheimer's disease (AD)
worldwide, AD is an unduly common form of dementia that exacts a heavy toll on affected …

Background Glutathione [GSH] is a major intracellular antioxidant that disposes peroxides
and protects neurons and glial cells from oxidative stress. In both schizophrenia and bipolar …

Background Clinical symptoms and neuropsychological deficits are longitudinally
associated with functional outcome in chronic psychiatric cohorts. The current study …

Glutathione (GSH) is an important antioxidant implicated in several physiological functions,
including the oxidation− reduction reaction balance and brain antioxidant defense against …

Every common psychiatric syndrome is genetically, neurobiologically and clinically
heterogeneous. This heterogeneity may reflect the dimensional variability of a single illness …

Background After 30 years of consensus-derived diagnostic categories in mental health, it is
time to head in new directions. Those categories placed great emphasis on enhanced …

Oxidative stress plays a key role in the pathophysiology of schizophrenia. While free radicals
produced by glutamatergic excess and oxidative metabolism have damaging effects on …

Schizophrenia continues to be an illness with poor outcome. Most mechanistic changes
occur many years before the first episode of schizophrenia; these are not reversible after the …

Patients with schizophrenia diverge in their clinical trajectories. Such diverge outcomes may
result from the resilience provided by antioxidant response system centered on glutathione …