Implications of adverse outcomes associated with antipsychotics in older patients with dementia: a 2011–2022 update

M Rogowska, M Thornton, B Creese, L Velayudhan… - Drugs & Aging, 2023 - Springer
Neuropsychiatric symptoms affect most patients with dementia over the course of the
disease. They include a wide variety of symptoms from apathy and depression to psychosis …

Associations between anticholinergic burden and adverse health outcomes in Parkinson disease

JAG Crispo, AW Willis, DP Thibault, Y Fortin, HD Hays… - PLoS …, 2016 - journals.plos.org
Background Elderly adults should avoid medications with anticholinergic effects since they
may increase the risk of adverse events, including falls, delirium, and cognitive impairment …

Neuropsychiatric manifestations in Alzheimer's disease patients: genetics and treatment options

AK Singh, R Malviya, A Prakash… - CNS & Neurological …, 2024 - benthamdirect.com
Background Alzheimer's disease (AD) is characterized by neuropsychiatric symptoms
(NPS), which cause great misery to those with dementia and those who care for them and …

Antipsychotic use in dementia: the relationship between neuropsychiatric symptom profiles and adverse outcomes

C Mueller, C John, G Perera, D Aarsland… - European journal of …, 2021 - Springer
Antipsychotic treatments are associated with safety concerns in people with dementia. The
authors aimed to investigate whether risk of adverse outcomes related to antipsychotic …

Protocol for DEprescribing and Care to reduce Antipsychotics in Dementia (DECADE)–A hybrid effectiveness-implementation pilot study

KS Benthien, LVJ Lech, H Birke, SM Jørgensen… - PloS One, 2023 - journals.plos.org
Introduction Behavioural and psychological symptoms of dementia (BPSD) should only
rarely and briefly be treated with antipsychotics. Despite recommendations to the contrary …

Microbial contamination and efficacy of disinfection procedures of companion robots in care homes

HL Bradwell, CW Johnson, J Lee, R Winnington, S Thill… - Plos one, 2020 - journals.plos.org
Background Paro and other robot animals can improve wellbeing for older adults and
people with dementia, through reducing depression, agitation and medication use …

A cluster-randomized trial of a complex intervention to encourage deprescribing antidepressants in nursing home residents with dementia: a study protocol

P Hølmkjær, A Holm, G Overbeck, MP Rozing - Trials, 2022 - Springer
Background The effectiveness of psychotropic medication on behavioral and psychological
symptoms of dementia (BPSD) is limited, while associated with a higher risk of adverse …

The longitudinal patterns of psychotropic drug prescriptions for subpopulations of community-dwelling older people with dementia: electronic health records based …

J Du, SIM Janus, M de Boer, SU Zuidema - BMC primary care, 2023 - Springer
Background Studies focusing on patterns of psychotropic drug prescriptions (PDPs) for
subpopulations of community-dwelling older people with dementia are lacking. Objective …

Associations between the use of specific psychotropic drugs and all-cause mortality among older adults in Germany: Results of the mortality follow-up of the German …

Y Du, IK Wolf, MA Busch, H Knopf - PLoS one, 2019 - journals.plos.org
Background Use of psychotropic drugs is common among older adults. Population-based
studies on the associations of psychotropic drug use with mortality are sparse. Objectives To …

Managing the behavioral and psychological symptoms of dementia

MF Mendez - Current Treatment Options in Neurology, 2022 - Springer
Abstract Purpose of Review Alzheimer's disease and related dementias are the source of
significant distress, impairment, and caregiver burden in aging populations. A prominent …