Oxazole compounds containing nitrogen and oxygen atoms in the five-membered aromatic
ring are readily able to bind with a variety of enzymes and receptors in biological systems …

The emergence of multi-drug-resistant bacteria is threatening to human health and life
around the world. In particular, methicillin-resistant Staphylococcus aureus (MRSA) causes …

Direct C–H functionalization of aromatic compounds is a useful synthetic strategy that has
garnered much attention because of its application to pharmaceuticals, agrochemicals, and …

Novel azo linked substituted benzimidazole, benzoxazole, and benzothiazole were
synthesized by diazo coupling and characterized by 1 H NMR, elemental analysis, FTIR and …

Isothiourea-catalyzed annulations between 2-acyl benzazoles and α, β-unsaturated acyl
ammonium intermediates are selectively tuned to form either lactam or lactone heterocycles …

Chiral borane–catalyzed reactions have recently emerged as a powerful tool for the
enantioselective production of chiral scaffolds. In this study, we demonstrated for the first …

Abstract Development in the area of acceptorless dehydrogenation (AD) and borrowing
hydrogen (BH) catalysis emerge as one of the potential tools for various C− C and C …

Nitrogen containing heterocyclic rings with an oxygen atom is considered as one of the best
combination in medicinal chemistry due to their diversified biological activities. Isoxazole, a …

In 2014, more than 80% of the marketed drugs in the US contained heterocyclic compounds,
which play a major role in the drug-discovery process, as one of the primary components …

Herein, we have carried out a structural optimization campaign to discover the novel anti-
tumor agents with our previously screened YQY-26 as the hit compound. A library of thirty …