Vagus nerve stimulation and the cardiovascular system

MJ Capilupi, SM Kerath… - Cold Spring …, 2020 - perspectivesinmedicine.cshlp.org
The vagus nerve plays an important role in maintaining physiological homeostasis, which
includes reflex pathways that regulate cardiac function. The link between vagus nerve …

Intermittent electrical stimulation of the right cervical vagus nerve in salt‐sensitive hypertensive rats: effects on blood pressure, arrhythmias, and ventricular …

EM Annoni, X Xie, SW Lee, I Libbus… - Physiological …, 2015 - Wiley Online Library
Hypertension (HTN) is the single greatest risk factor for potentially fatal cardiovascular
diseases. One cause of HTN is inappropriately increased sympathetic nervous system …

Atrial GIRK channels mediate the effects of vagus nerve stimulation on heart rate dynamics and arrhythmogenesis

SW Lee, A Anderson, PA Guzman, A Nakano… - Frontiers in …, 2018 - frontiersin.org
Diminished parasympathetic influence is central to the pathogenesis of cardiovascular
diseases, including heart failure and hypertension. Stimulation of the vagus nerve has …

Chronic low-level vagus nerve stimulation improves long-term survival in salt-sensitive hypertensive rats

EM Annoni, D Van Helden, Y Guo, B Levac… - Frontiers in …, 2019 - frontiersin.org
Chronic hypertension (HTN) affects more than 1 billion people worldwide, and is associated
with an increased risk of cardiovascular disease. Despite decades of promising research …

Sex differences in vagus nerve stimulation effects on rat cardiovascular and immune systems

F Yaghouby, K Jang, U Hoang, S Asgari… - Frontiers in …, 2020 - frontiersin.org
Background Investigations into the benefits of vagus nerve stimulation (VNS) through pre-
clinical and clinical research have led to promising findings for treating several disorders …

Chronic cyclic vagus nerve stimulation has beneficial electrophysiological effects on healthy hearts in the absence of autonomic imbalance

SW Lee, Q Li, I Libbus, X Xie… - Physiological …, 2016 - Wiley Online Library
Cardiovascular disease degrades the regulatory function of the autonomic nervous system.
Cyclic vagus nerve stimulation (VNS) is an already FDA‐approved therapy for drug‐resistant …

Stochastic vagus nerve stimulation affects acute heart rate dynamics in rats

SW Lee, K Kulkarni, EM Annoni, I Libbus… - PloS one, 2018 - journals.plos.org
Vagus nerve stimulation (VNS) is an approved therapy for treatment of epilepsy and
depression. While also shown to be promising in several preclinical and clinical studies to …

An ASIC system for closed-loop blood pressure modulation through right cervical vagus nerve stimulation

JV Shah, BJ Collar, E Ditslear… - IEEE Transactions on …, 2022 - ieeexplore.ieee.org
Objective: Heart disease is the leading cause of death worldwide. Hypertension is an
important precursor and the most common risk factor to heart failure. While some patients …

[PDF][PDF] Development of a closed-loop, implantable electroceutical device for glaucoma

J Shah - 2021 - hammer.purdue.edu
Glaucoma is the global leading cause of irreversible blindness and is expected to increase
in prevalence [1], unless better treatments are developed to slow or stop the onset of …

Benchtop optical mapping approaches to study arrhythmias

K Kulkarni, SW Lee, EG Tolkacheva - Engineering in Medicine, 2019 - Elsevier
This chapter offers an overview of optical mapping concepts and provides details related to
various applications of this technique to visualize the normal and abnormal rhythms of the …