Azomethine ylides are nitrogen-based three-atom components commonly used in [3+ 2]-
cycloaddition reactions with various unsaturated 2π-electron components. These reactions …

Objective: The spirooxindole heterocyclic scaffold is found in many natural products and has
been identified as an important bioactive agent. Background: Over the past few decades …

Novel, quinolone–fluoroquinolone conjugates 10a–f, 11a–f, 13a–f and 14a–f with amino
acid linkers were synthesized in good yields utilizing benzotriazole chemistry. Antibacterial …

Novel fluoroquinolone–pyrazine conjugates 7a–h with amino acid linkers were synthesized
in good yields utilizing benzotriazole chemistry. Antimicrobial bioassay showed that the …

Click chemistry technique led to novel 1, 2, 3-triazole-quinine conjugates 8a–g, 10a–o, 11a–
h and 13 utilizing benzotriazole-mediated synthetic approach with excellent yields. Some of …

The broad spectrum of curcumin's beneficial properties has encouraged medicinal
researchers to investigate its therapeutic efficacy against diverse diseases. The clinical …

Cancer is one of the most significant health challenges worldwide. Various techniques, tools
and therapeutics/materials have been developed in the last few decades for the treatment of …

Novel, cyclic peptidomimetics were synthesized by facile acylation reactions using
benzotriazole chemistry. Microbiological testing of the synthesized compounds revealed an …

Antitumor active dispiro [3H-indole-3, 2′-pyrrolidine-3′, 3′′-piperidine]-2 (1H), 4′′-
diones 11–19 were regioselectively synthesized via azomethine ylide cycloaddition …

3D-pharmacophore and 2D-QSAR modeling studies describe the anti-oncological
properties of spiro-alkaloids. The dispiro [2H-indene-2, 3′-pyrrolidine-2′, 3′′-[3H] …