Apoptotic cells were shown to induce dendritic cell immune tolerance. We applied a
proteomic approach to identify molecules that are secreted from apoptotic monocytes, and …

Inflammation plays a central role in the processes associated with neurodegeneration. The
inflammatory response is mediated by activated microglia that release inflammatory …

Objectives The role of proteases in the regulation of apoptosis is becoming increasingly
apparent. Whilst many of these proteases are already characterised, some have yet to be …

The livers of soles (Solea senegalensis) injected with subacute doses of cadmium (Cd),
benzo [a] pyrene (B [a] P), or their combination, were screened for alterations to cytosolic …

The cysteine carboxypeptidase cathepsin X is an important player in degenerative
processes under normal ageing and pathological conditions. In the present study, we …

Viruses encode suppressors of cell death to block intrinsic and extrinsic host-initiated death
pathways that reduce viral yield as well as control the termination of infection …

Six-mercaptopurine (6-MP) is a pro-drug widely used in treatment of various diseases,
including acute lymphoblastic leukaemia (ALL). Side-effects of thiopurine therapy have been …

Serine protease inhibitors Na-tosyl-L-lysinyl-chloromethylketone (TLCK) and N-tosyl-L-
phenylalaninylchloromethylketone (TPCK) exhibit multiple effects on cell death pathways in …

Solid lipid nanoparticles (SLN) have been praised for their advantageous drug delivery
properties such as biocompatibility, controlled release and passive drug targeting. However …

Microglia are resident macrophages in the central nervous system that are involved in
immune responses driven by Toll-like receptors (TLRs). Microglia-mediated inflammation …