Immunomodulation by mesenchymal stem cells and clinical experience

K Le Blanc, O Ringden - Journal of internal medicine, 2007 - Wiley Online Library
Mesenchymal stem cells (MSCs) from adult marrow can differentiate in vitro and in vivo into
various cell types, such as bone, fat and cartilage. MSCs preferentially home to damaged …

Biomanufacturing for clinically advanced cell therapies

A Aijaz, M Li, D Smith, D Khong, C LeBlon… - Nature biomedical …, 2018 - nature.com
The achievements of cell-based therapeutics have galvanized efforts to bring cell therapies
to the market. To address the demands of the clinical and eventual commercial-scale …

Mesenchymal stem cells for treatment of therapy-resistant graft-versus-host disease

O Ringdén, M Uzunel, I Rasmusson… - …, 2006 - journals.lww.com
Background. Mesenchymal stem cells (MSC) have immunomodulatory effects. The aim was
to study the effect of MSC infusion on graft-versus-host disease (GVHD). Methods. We gave …

Isolation and characterization of human umbilical cord mesenchymal stem cells with hematopoiesis-supportive function and other potentials

LL Lu, YJ Liu, SG Yang, QJ Zhao, X Wang… - …, 2006 - haematologica.org
BACKGROUND AND OBJECTIVES: Adult bone marrow (BM) is the major source of
mesenchymal stem cells (MSC) for cell therapy. However, aspiration of BM involves invasive …

Human umbilical cord perivascular (HUCPV) cells: a source of mesenchymal progenitors

R Sarugaser, D Lickorish, D Baksh, MM Hosseini… - Stem …, 2005 - academic.oup.com
We describe the isolation of a nonhematopoietic (CD45−, CD34−, SH2+, SH3+, Thy‐1+,
CD44+) human umbilical cord perivascular (HUCPV) cell population. Each HUCPV cell …

Mesenchymal stromal cell-derived extracellular vesicles rescue radiation damage to murine marrow hematopoietic cells

S Wen, M Dooner, Y Cheng, E Papa, M Del Tatto… - Leukemia, 2016 - nature.com
Mesenchymal stromal cells (MSCs) have been shown to reverse radiation damage to
marrow stem cells. We have evaluated the capacity of MSC-derived extracellular vesicles …

Immunomodulatory effects of fetal and adult mesenchymal stem cells

K Le Blanc - Cytotherapy, 2003 - Elsevier
Mesenchymal stem cells (MSC) derived from adult BM or fetal liver form several
mesenchymal tissues after appropriate stimulation. Reports indicate that MSC have unique …

Concise review: hitting the right spot with mesenchymal stromal cells

J Tolar, K Le Blanc, A Keating, BR Blazar - Stem cells, 2010 - academic.oup.com
Mesenchymal stromal cells or mesenchymal stem cells (MSCs) have captured considerable
scientific and public interest because of their potential to limit physical and immune injury, to …

[HTML][HTML] Mesenchymal stem cells: paradoxes of passaging

EH Javazon, KJ Beggs, AW Flake - Experimental hematology, 2004 - Elsevier
The field of stem cell biology continues to evolve with the ongoing characterization of
multiple types of stem cells with their inherent potential for experimental and clinical …

Comparison of immunomodulatory properties of mesenchymal stem cells derived from adult human tissues

KH Yoo, IK Jang, MW Lee, HE Kim, MS Yang, Y Eom… - Cellular …, 2009 - Elsevier
Mesenchymal stem cells (MSCs), which evoke only minimal immune reactivity, may have
anti-inflammatory and immunomodulatory effects. In this study, we conducted a comparative …