[HTML][HTML] Molecular insights into the pathogenic impact of vitamin D deficiency in neurological disorders

MJ Anwar, SK Alenezi, AH Alhowail - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Neurological disorders are the major cause of disability, leading to a decrease in quality of
life by impairing cognitive, sensorimotor, and motor functioning. Several factors have been …

Strategies for neuroprotection in multiple sclerosis and the role of calcium

M Enders, T Heider, A Ludwig, S Kuerten - International Journal of …, 2020 - mdpi.com
Calcium ions are vital for maintaining the physiological and biochemical processes inside
cells. The central nervous system (CNS) is particularly dependent on calcium homeostasis …

Antiepileptogenic effects of Anakinra, lamotrigine and their combination in a Lithium–pilocarpine model of temporal lobe epilepsy in rats

OE Zubareva, DS Sinyak, AD Kalita, AV Griflyuk… - International Journal of …, 2023 - mdpi.com
Temporal lobe epilepsy is a common, chronic disorder with spontaneous seizures that is
often refractory to drug therapy. A potential cause of temporal lobe epilepsy is primary brain …

Anticonvulsant and antioxidant effects of lamotrigine on pilocarpine-induced status epilepticus in mice

K Onishi, T Kamida, M Fujiki, Y Momii, K Sugita - NeuroReport, 2023 - journals.lww.com
Objectives The anticonvulsant and antioxidant effects of lamotrigine on status epilepticus
(SE) are incompletely understood. We assessed these effects of lamotrigine on pilocarpine …

Cognitive comorbidities in the rat pilocarpine model of epilepsy

A Guarino, P Pignata, F Lovisari, L Asth… - Frontiers in …, 2024 - frontiersin.org
Patients with epilepsy are prone to cognitive decline, depression, anxiety and other
behavioral disorders. Cognitive comorbidities are particularly common and well …

Neuroinflammation impact in epileptogenesis and new treatment strategy

AM Mahfoz, N Shahzad - Behavioural pharmacology, 2019 - journals.lww.com
Epilepsy is considered a major serious chronic neurological disorder, characterized by
recurrent seizures. It is usually associated with a history of a lesion in the nervous system …

New insights into the effects of vinpocetine against neurobehavioral comorbidities in a rat model of temporal lobe epilepsy via the downregulation of the hippocampal …

SS El-Sayed, MF El-Yamany, HA Salem… - Journal of Pharmacy …, 2021 - academic.oup.com
Objectives As one of the most frequent worldwide neurological disorders, epilepsy is an
alteration of the central nervous system (CNS) characterized by abnormal increases in …

Effects of vitamin D on drugs: Response and disposal

J Peng, Y Liu, J Xie, G Yang, Z Huang - Nutrition, 2020 - Elsevier
Vitamin D supplementation and vitamin D deficiency are common in clinical experience and
in daily life. Vitamin D not only promotes calcium absorption and immune regulation, but …

Molecular docking to investigate the inhibitory activity and the role of nitric oxide in anticonvulsant effects of vitamin D on pentylenetetrazole‑induced epileptic seizures …

R Akkaya, B Akkaya, RO Bello - Journal of Molecular Structure, 2023 - Elsevier
Despite the great breakthroughs in the field of epilepsy studies, the present drugs are
ineffective in one-third of the patients, as well as without providing a definite treatment. There …

Various pharmacological agents in the pipeline against intractable epilepsy

A Waris, M Asim, A Ullah… - Archiv der …, 2024 - Wiley Online Library
Epilepsy is a noncommunicable chronic neurological disorder affecting people of all ages,
with the highest prevalence in low and middle‐income countries. Despite the …