A state-of-the-art review on the recent advances of niosomes as a targeted drug delivery system

S Yasamineh, P Yasamineh, HG Kalajahi… - International journal of …, 2022 - Elsevier
The buildup of nonionic surfactants in the aqueous environment produces niosomes. The
usage of niosomes is becoming increasingly frequent due to their sustainability, low cost of …

Nanovesicular-mediated intranasal drug therapy for neurodegenerative disease

S Singh, R Shukla - AAPS PharmSciTech, 2023 - Springer
Numerous neurodegenerative conditions, such as Alzheimer's, Huntington's, Parkinson's,
amyotrophic lateral sclerosis, and glioblastoma multiform are now becoming significant …

[HTML][HTML] Novel nasal niosomes loaded with lacosamide and coated with chitosan: A possible pathway to target the brain to control partial-onset seizures

AS Tulbah, MH Elkomy, RM Zaki, HM Eid… - International journal of …, 2023 - Elsevier
This work aimed to develop and produce lacosamide-loaded niosomes coated with chitosan
(LCA-CTS-NSM) using a thin-film hydration method and the Box-Behnken design. The effect …

[HTML][HTML] pH-sensitive in situ gel of mirtazapine Invasomes for rectal drug delivery: Protruded bioavailability and anti-depressant efficacy

EM Eissa, AM El Sisi, MA Bekhet, FIA El-Ela… - Pharmaceuticals, 2024 - mdpi.com
The present research emphasizes fabrication alongside the assessment of an innovative
nano-vesicular membranous system known as invasomes (NVMs) laden with Mirtazapine …

Intranasal nanotransferosomal gel for quercetin brain targeting: I. Optimization, characterization, brain localization, and cytotoxic studies

MH Elkomy, RM Zaki, OA Alsaidan, M Elmowafy… - Pharmaceutics, 2023 - mdpi.com
Numerous neurological disorders have a pathophysiology that involves an increase in free
radical production in the brain. Quercetin (QER) is a nutraceutical compound that shields the …

Propranolol-loaded limonene-based microemulsion thermo-responsive mucoadhesive nasal nanogel: design, in vitro assessment, ex vivo permeation, and brain …

KK Abla, S Domiati, R El Majzoub, MM Mehanna - Gels, 2023 - mdpi.com
Propranolol is the first-line drug for managing migraine attacks. D-limonene is a citrus oil
known for its neuroprotective mechanism. Thus, the current work aims to design a thermo …

A comprehensive and updated review on the applications of vesicular drug delivery systems in treatment of brain disorders: A shelter against storms

MA Rajizadeh, S Motamedy, Y Mir… - Journal of Drug Delivery …, 2023 - Elsevier
Vesicular drug delivery carriers, a subgroup of colloidal drug delivery systems (CDDS), can
be defined as highly ordered assemblies consisting of one or more concentric bilayers …

[HTML][HTML] Brain targeting of citicoline sodium via hyaluronic acid-decorated novel nano-transbilosomes for mitigation of Alzheimer's disease in a rat model: formulation …

KM AbouElhassan, HA Sarhan… - International Journal …, 2022 - ncbi.nlm.nih.gov
Background Alzheimer's disease (AD) is one of the furthermost advanced
neurodegenerative disorders resulting in cognitive and behavioral impairment. Citicoline …

The Encapsulation of Citicoline within Solid Lipid Nanoparticles Enhances Its Capability to Counteract the 6-Hydroxydopamine-Induced Cytotoxicity in Human …

A Margari, AG Monteduro, S Rizzato, L Capobianco… - Pharmaceutics, 2022 - mdpi.com
(1) Backgrond: Considering the positive effects of citicoline (CIT) in the management of
some neurodegenerative diseases, the aim of this work was to develop CIT-Loaded Solid …

Rizatriptan loaded bilosomes for nose to brain delivery: Fabrication, statistical optimization, and biological evaluation

NK Alruwaili, OA Alsaidan, A Zafar, HH Alhassan… - Journal of Drug Delivery …, 2025 - Elsevier
Rizatriptan (RTP) is an anti-migraine drug and after oral administration, it exhibits low
bioavailability (45%) due to high first-pass hepatic metabolism. Therefore, to resolve this …