Obesity, fat mass and immune system: role for leptin

V Francisco, J Pino, V Campos-Cabaleiro… - Frontiers in …, 2018 - frontiersin.org
Obesity is an epidemic disease characterized by chronic low-grade inflammation associated
with a dysfunctional fat mass. Adipose tissue is now considered an extremely active …

The role of adipokines in chronic inflammation

P Mancuso - ImmunoTargets and therapy, 2016 - Taylor & Francis
Adipose tissue has traditionally been defined as connective tissue that stores excess
calories in the form of triacylglycerol. However, the physiologic functions attributed to …

Leptin in inflammation and autoimmunity

A La Cava - Cytokine, 2017 - Elsevier
After its discovery as a key controller of metabolic function, leptin has been later extensively
implicated in additional functions including important modulatory activities on the innate and …

COVID-19 severity in obesity: leptin and inflammatory cytokine interplay in the link between high morbidity and mortality

R Maurya, P Sebastian, M Namdeo… - Frontiers in …, 2021 - frontiersin.org
Obesity is one of the foremost risk factors in coronavirus infection resulting in severe illness
and mortality as the pandemic progresses. Obesity is a well-known predisposed chronic …

Role of leptin in the activation of immune cells

P Fernández-Riejos, S Najib… - Mediators of …, 2010 - Wiley Online Library
Adipose tissue is an active endocrine organ that secretes various humoral factors
(adipokines), and its shift to production of proinflammatory cytokines in obesity likely …

Metabolic syndrome and the lung

CW Baffi, L Wood, D Winnica, PJ Strollo Jr, MT Gladwin… - Chest, 2016 - Elsevier
A link between metabolic syndrome (MetS) and lung diseases has been observed in several
cross-sectional and longitudinal studies. This syndrome has been identified as an …

Leptin as an immunomodulator

C Procaccini, E Jirillo, G Matarese - Molecular aspects of medicine, 2012 - Elsevier
Leptin is an adipocyte-derived hormone/cytokine that links nutritional status with
neuroendocrine and immune functions. In humans, leptin influences energy homeostasis …

Leptin in immunology

G Matarese, S Moschos… - The Journal of Immunology, 2005 - journals.aai.org
Leptin is an adipokine which conveys information on energy availability. In humans, leptin
influences energy homeostasis and regulates neuroendocrine function primarily in states of …

An official American Thoracic Society Workshop report: obesity and asthma

AE Dixon, F Holguin, A Sood, CM Salome… - Proceedings of the …, 2010 - atsjournals.org
Rationale: The developed world is currently facing an epidemic of obesity. With the
increased prevalence of obesity has come the recognition that obesity is a risk factor for …

Leptin and inflammation

N Iikuni, QL Kwan Lam, L Lu… - Current immunology …, 2008 - ingentaconnect.com
The past few years of research on leptin have provided important information on the link
between metabolism and immune homeostasis. Adipocytes influence not only the endocrine …