Functional cure of chronic hepatitis B (CHB)—or hepatitis B surface antigen (HBsAg) loss
after 24 weeks off therapy—is now the goal of treatment, but is rarely achieved with current …

HIV reverse transcriptase (RT) inhibitors are the important components of highly active
antiretroviral therapies (HAARTs) for anti-HIV treatment and pre-exposure prophylaxis in …

To facilitate the achieving of the goal of" eliminating viral hepatitis as a major public health
threat by 2030" set by the World Health Organization, the Chinese Society of Hepatology …

Chronic HBV infection can hardly be cured due to the persistence of an intrahepatic pool of
viral covalently closed circular DNA (cccDNA) transcription template, which is refractory to …

Nucleoside and nucleotide analogues are essential antivirals in the treatment of infectious
diseases such as human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C …

Background Serum hepatitis B virus RNA (HBV RNA) has been reported to be a surrogate
marker of intrahepatic cccDNA during nucleos (t) ide analogs therapy. However, in HBeAg …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a global pandemic
of coronavirus disease in 2019 (COVID-19). Genome surveillance is a key method to track …

Abstract Background and Aims Functional cure is difficult to achieve using current antiviral
therapies; moreover, limited data are available regarding treatment outcomes in children …

Standard treatment of hepatitis delta virus (HDV) infection remains pegylated‐interferon alfa
(peg‐IFNα) in most centers, which is not only associated with rather low efficacy but several …

Background Biomarkers such as quantitative HBsAg (qHBsAg), quantitative hepatitis B virus
(HBV) core‐related antigen (qHBcrAg) and HBV RNA may be useful in predicting HBsAg …