A history of exploring cancer in context
S Maman, IP Witz - Nature Reviews Cancer, 2018 - nature.com
The concept that progression of cancer is regulated by interactions of cancer cells with their
microenvironment was postulated by Stephen Paget over a century ago. Contemporary …
microenvironment was postulated by Stephen Paget over a century ago. Contemporary …
CSF-1 receptor signaling in myeloid cells
ER Stanley, V Chitu - Cold Spring Harbor perspectives …, 2014 - cshperspectives.cshlp.org
The CSF-1 receptor (CSF-1R) is activated by the homodimeric growth factors colony-
stimulating factor-1 (CSF-1) and interleukin-34 (IL-34). It plays important roles in …
stimulating factor-1 (CSF-1) and interleukin-34 (IL-34). It plays important roles in …
Targeting tumor-associated macrophages with anti-CSF-1R antibody reveals a strategy for cancer therapy
CH Ries, MA Cannarile, S Hoves, J Benz, K Wartha… - Cancer cell, 2014 - cell.com
Macrophage infiltration has been identified as an independent poor prognostic factor in
several cancer types. The major survival factor for these macrophages is macrophage …
several cancer types. The major survival factor for these macrophages is macrophage …
PDGF receptor mutations in human diseases
E Guérit, F Arts, G Dachy, B Boulouadnine… - Cellular and Molecular …, 2021 - Springer
PDGFRA and PDGFRB are classical proto-oncogenes that encode receptor tyrosine kinases
responding to platelet-derived growth factor (PDGF). PDGFRA mutations are found in …
responding to platelet-derived growth factor (PDGF). PDGFRA mutations are found in …
[HTML][HTML] Role and significance of c-KIT receptor tyrosine kinase in cancer: A review
Abstract c-kit is a classical proto-oncogene that encodes a receptor tyrosine kinase (RTK)
that responds to stem cell factor (SCF). C-KIT signaling is a critical regulator of cell …
that responds to stem cell factor (SCF). C-KIT signaling is a critical regulator of cell …
Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma
The pro-inflammatory cytokine thymic stromal lymphopoietin (TSLP) is pivotal to the
pathophysiology of widespread allergic diseases mediated by type 2 helper T cell (Th2) …
pathophysiology of widespread allergic diseases mediated by type 2 helper T cell (Th2) …
BET protein antagonist JQ1 is synergistically lethal with FLT3 tyrosine kinase inhibitor (TKI) and overcomes resistance to FLT3-TKI in AML cells expressing FLT-ITD
Recently, treatment with bromodomain and extraterminal protein antagonist (BA) such as
JQ1 has been shown to inhibit growth and induce apoptosis of human acute myelogenous …
JQ1 has been shown to inhibit growth and induce apoptosis of human acute myelogenous …
Structural analysis reveals that the cytokine IL-17F forms a homodimeric complex with receptor IL-17RC to drive IL-17RA-independent signaling
A Goepfert, S Lehmann, J Blank, F Kolbinger… - Immunity, 2020 - cell.com
Summary Interleukin-17A (IL-17A), IL-17F, and IL-17A/F heterodimers are key cytokines of
the innate and adaptive immune response. Dysregulation of the IL-17 pathway contributes to …
the innate and adaptive immune response. Dysregulation of the IL-17 pathway contributes to …
IL-34 and CSF-1: similarities and differences
Y Nakamichi, N Udagawa, N Takahashi - Journal of bone and mineral …, 2013 - Springer
Abstract Colony-stimulating factor-1 (CSF-1) is widely expressed and considered to regulate
the development, maintenance, and function of mononuclear phagocyte lineage cells such …
the development, maintenance, and function of mononuclear phagocyte lineage cells such …
Targeting oncogenic signaling in mutant FLT3 acute myeloid leukemia: the path to least resistance
The identification of recurrent driver mutations in genes encoding tyrosine kinases has
resulted in the development of molecularly-targeted treatment strategies designed to …
resulted in the development of molecularly-targeted treatment strategies designed to …