PIWI-interacting RNAs: small RNAs with big functions
In animals, PIWI-interacting RNAs (piRNAs) of 21–35 nucleotides in length silence
transposable elements, regulate gene expression and fight viral infection. piRNAs guide …
transposable elements, regulate gene expression and fight viral infection. piRNAs guide …
RGG/RG motif regions in RNA binding and phase separation
PA Chong, RM Vernon, JD Forman-Kay - Journal of molecular biology, 2018 - Elsevier
Abstract RGG/RG motifs are RNA binding segments found in many proteins that can partition
into membraneless organelles. They occur in the context of low-complexity disordered …
into membraneless organelles. They occur in the context of low-complexity disordered …
[HTML][HTML] Phase transition of a disordered nuage protein generates environmentally responsive membraneless organelles
Cells chemically isolate molecules in compartments to both facilitate and regulate their
interactions. In addition to membrane-encapsulated compartments, cells can form …
interactions. In addition to membrane-encapsulated compartments, cells can form …
PIWI-interacting small RNAs: the vanguard of genome defence
PIWI-interacting RNAs (piRNAs) are a distinct class of small non-coding RNAs that form the
piRNA-induced silencing complex (piRISC) in the germ line of many animal species. The …
piRNA-induced silencing complex (piRISC) in the germ line of many animal species. The …
RISC assembly: Coordination between small RNAs and Argonaute proteins
H Kobayashi, Y Tomari - Biochimica et Biophysica Acta (BBA)-Gene …, 2016 - Elsevier
Non-coding RNAs generally form ribonucleoprotein (RNP) complexes with their partner
proteins to exert their functions. Small RNAs, including microRNAs, small interfering RNAs …
proteins to exert their functions. Small RNAs, including microRNAs, small interfering RNAs …
eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation
AC Gingras, B Raught… - Annual review of …, 1999 - annualreviews.org
▪ Abstract Eukaryotic translation initiation factor 4F (eIF4F) is a protein complex that mediates
recruitment of ribosomes to mRNA. This event is the rate-limiting step for translation under …
recruitment of ribosomes to mRNA. This event is the rate-limiting step for translation under …
Sequence-specific polyampholyte phase separation in membraneless organelles
Liquid-liquid phase separation of charge-and/or aromatic-enriched intrinsically disordered
proteins (IDPs) is critical in the biological function of membraneless organelles. Much of the …
proteins (IDPs) is critical in the biological function of membraneless organelles. Much of the …
The DEAD-box protein family of RNA helicases
RNA helicases of the DEAD-box protein family have been shown to participate in every
aspect of RNA metabolism. They are present in most organisms where they work as RNA …
aspect of RNA metabolism. They are present in most organisms where they work as RNA …
Specialized piRNA pathways act in germline and somatic tissues of the Drosophila ovary
Summary In Drosophila gonads, Piwi proteins and associated piRNAs collaborate with
additional factors to form a small RNA-based immune system that silences mobile elements …
additional factors to form a small RNA-based immune system that silences mobile elements …
A canine distemper virus epidemic in Serengeti lions (Panthera leo)
ME Roelke-Parker, L Munson, C Packer, R Kock… - Nature, 1996 - nature.com
CANINE distemper virus (CDV) is thought to have caused several fatal epidemics in canids
within the Serengeti–Mara ecosystem of East Africa, affecting silver-backed jackals (Canis …
within the Serengeti–Mara ecosystem of East Africa, affecting silver-backed jackals (Canis …