There is a huge need for novel therapeutic and preventative approaches to Alzheimer's
disease (AD) and neuroinflammation seems to be one of the most fascinating solutions. The …

Alzheimer's disease is a chronic and progressive brain neurodegenerative disease affecting
over 30 million people globally. Currently, no effective treatment is available due to multiple …

Alzheimer's disease (AD) is an age-related multifactorial neurodegenerative disorder
characterized by severe central cholinergic neuronal loss, gradually contributing to cognitive …

Alzheimer's disease (AD) is a progressive neurodegenerative disease, which has brought a
huge burden to the world. The current therapeutic approach of one-molecule-one-target …

Alzheimer's disease (AD) is the most prevalent form of dementia in the elderly population
worldwide. Despite the major unmet clinical need, no new medications for the treatment of …

Alzheimer's disease's pathophysiology is still a conundrum. Growing number of evidences
have elucidated the involvement of oxidative stress in the pathology of AD rendering it a …

TRPM2 channel is activated by the increase of hypoxia (HYP)-mediated excessive
mitochondrial (mROS) and cytosolic (cROS) free reactive oxygen species generation and …

Introduction The accumulation of oxidative stress, neuroinflammation and abnormal
aggregation of amyloid β-peptide (Aβ) have been shown to induce synaptic dysfunction and …

Memantine (3, 5-dimethyladamantan-1-amine) is an orally active, noncompetitive N-methyl-
D-aspartate receptor (NMDAR) antagonist approved for treatment of moderate-to-severe …

Alzheimer's disease (AD) is the most common type of dementia leading to progressive
memory loss and cognitive impairment. Considering that pharmacological treatment options …