Living organisms are continuously exposed to a myriad of DNA damaging agents that can
impact health and modulate disease‐states. However, robust DNA repair and damage …

The Fanconi anaemia pathway repairs DNA interstrand crosslinks (ICLs) in the genome. Our
understanding of this complex pathway is still evolving, as new components continue to be …

Summary Phosphatidylinositol 3′ OH kinase (PI3K) signaling and FOXO transcription
factors play opposing roles at several B cell developmental stages. We show here abundant …

BRCA1/2 proteins function in homologous recombination (HR)-mediated DNA repair and
cooperate with Fanconi anemia (FA) proteins to maintain genomic integrity through …

Alternative end joining (Alt-EJ) chromosomal break repair involves bypassing classical non-
homologous end joining (c-NHEJ), and such repair causes mutations often with …

Fanconi anaemia (FA) is the most frequent inherited bone marrow failure syndrome, due to
mutations in genes encoding proteins involved in replication fork protection, DNA interstrand …

Persistent dysregulation of the DNA damage response and repair in cells causes genomic
instability. The resulting genetic changes permit alterations in growth and proliferation …

Cells are constantly exposed to endogenous and exogenous stresses that can result in DNA
damage. In response, they have evolved complex pathways to maintain genomic integrity …

Fanconi anemia (FA) is a rare disease, in which homozygous or compound heterozygous
inactivating mutations in any of 21 genes lead to genomic instability, early-onset bone …

DNA interstrand cross-links (ICLs) represent a major barrier blocking DNA replication fork
progression. ICL accumulation results in growth arrest and cell death—particularly in cell …