Fertility after curative therapy for sickle cell disease: a comprehensive review to guide care

RS Nickel, JY Maher, MH Hsieh, MF Davis… - Journal of clinical …, 2022 - mdpi.com
Curative therapy for sickle cell disease (SCD) currently requires gonadotoxic conditioning
that can impair future fertility. Fertility outcomes after curative therapy are likely affected by …

Knowledge gaps in reproductive and sexual health in girls and women with sickle cell disease

LH Pecker, D Sharma, A Nero… - British journal of …, 2021 - Wiley Online Library
There is an immediate need to address long‐standing questions about the reproductive
health of girls and women with sickle cell disease (SCD). There are many SCD‐related …

Expecting more: the case for incorporating fertility services into comprehensive sickle cell disease care

LH Pecker, E Oteng-Ntim, A Nero, S Lanzkron… - The Lancet …, 2023 - thelancet.com
Assisted reproductive technologies (ART) are not yet systematically available to people with
sickle cell disease or their parents. Fertility care for these groups requires addressing sickle …

Diminished ovarian reserve in young women with sickle cell anemia

LH Pecker, S Hussain, J Mahesh… - Blood, The Journal …, 2022 - ashpublications.org
Women with sickle cell anemia (SCA) have higher rates of diminished ovarian reserve
(DOR) than age-matched controls. Pecker et al report a small study of patients with SCA that …

The evolving treatment landscape for children with sickle cell disease

SA Jacob, R Talati, J Kanter - The Lancet Child & Adolescent Health, 2023 - thelancet.com
Sickle cell disease is the most common inherited pathological haemoglobinopathy. Over the
past 30 years, disease-related morbidity and mortality have improved in high-income …

Incorporating gonadal health counseling into pediatric care of sickle cell patients

LR Meacham, LH Pecker, B Gee, A Mishkin - Hematology, 2022 - ashpublications.org
Discussions regarding gonadal function and possible disease or treatment-related ovarian
or testicular dysfunction, sexual dysfunction, and possible future infertility can be challenging …

[PDF][PDF] Go the distance: reproductive health care for people with sickle cell disease

LH Pecker, KHM Kuo - Hematology/oncology clinics of North America, 2022 - Elsevier
This review provides an overview of reproductive and sexual healthcare concerns for
individuals with SCD and their families. Reproductive and sexual health care are …

Desire for biological parenthood and patient counseling on the risk of infertility among adolescents and adults with hemoglobinopathies

AC Radauer‐Plank, T Diesch‐Furlanetto… - Pediatric blood & …, 2023 - Wiley Online Library
Background Both diagnosis and treatment of hemoglobinopathies have been associated
with an increased risk of fertility impairment. German guidelines recommend annual …

Hydroxyurea (hydroxycarbamide) for sickle cell disease

AE Rankine-Mullings, SJ Nevitt - Cochrane Database of …, 2022 - cochranelibrary.com
Background Sickle cell disease (SCD) is one of the most common inherited diseases
worldwide. It is associated with lifelong morbidity and a reduced life expectancy …

Infertility and treatment‐seeking practices among females and males with sickle cell disease in the Sickle Cell Disease Implementation Consortium registry

E Stevenson, P Tanabe, M Knisely… - Pediatric blood & …, 2023 - Wiley Online Library
Objective To describe the prevalence of infertility and infertility treatment seeking among
people enrolled in the Sickle Cell Disease Implementation Consortium (SCDIC) registry and …