Recent advances in understanding the inflammatory response in malaria: a review of the dual role of cytokines

GL Popa, MI Popa - Journal of immunology research, 2021 - Wiley Online Library
Malaria is a serious and, in some unfortunate cases, fatal disease caused by a parasite of
the Plasmodium genus. It predominantly occurs in tropical areas where it is transmitted …

Human NCR3 gene variants rs2736191 and rs11575837 alter longitudinal risk for development of pediatric malaria episodes and severe malarial anemia

CO Onyango, Q Cheng, EO Munde, E Raballah… - BMC genomics, 2023 - Springer
Background Plasmodium falciparum malaria is a leading cause of pediatric morbidity and
mortality in holoendemic transmission areas. Severe malarial anemia [SMA, hemoglobin …

Complement component 3 mutations alter the longitudinal risk of pediatric malaria and severe malarial anemia

E Raballah, SB Anyona, Q Cheng… - Experimental …, 2022 - journals.sagepub.com
Severe malarial anemia (SMA) is a leading cause of childhood morbidity and mortality in
holoendemic Plasmodium falciparum transmission regions. To gain enhanced …

The Interface Between Inflammatory Mediators and MicroRNAs in Plasmodium vivax Severe Thrombocytopenia

MLS Santos, RS Coimbra, TN Sousa… - Frontiers in Cellular …, 2021 - frontiersin.org
Severe thrombocytopenia can be a determinant factor in the morbidity of Plasmodium vivax,
the most widespread human malaria parasite. Although immune mechanisms may drive P …

[HTML][HTML] Transcriptomic and Proteomic Insights into Host Immune Responses in Pediatric Severe Malarial Anemia: Dysregulation in HSP60-70-TLR2/4 Signaling and …

CO Onyango, SB Anyona, I Hurwitz, E Raballah… - Pathogens, 2024 - mdpi.com
Severe malarial anemia (SMA, Hb< 6.0 g/dL) is a leading cause of childhood morbidity and
mortality in holoendemic Plasmodium falciparum transmission zones. This study explored …

Nonsynonymous amino acid changes in the α-chain of complement component 5 influence longitudinal susceptibility to Plasmodium falciparum infections and severe …

E Raballah, K Wilding, SB Anyona, EO Munde… - Frontiers in …, 2022 - frontiersin.org
Background: Severe malarial anemia (SMA; Hb< 5.0 g/dl) is a leading cause of childhood
morbidity and mortality in holoendemic Plasmodium falciparum transmission regions such …

Integrated Analysis of Cytokine Profiles in Malaria Patients Discloses Selective Upregulation of TGF-β1, β3, and IL-9 in Mild Clinical Presentation

EL Ndoricyimpaye, J Van Snick, JD Niyoyita… - International Journal of …, 2022 - mdpi.com
The proper control of Plasmodium infection requires a finely balanced immune response.
Here, we evaluated the implication of TGF-β1 and TGF-β3 in this process using novel …

Pro‐and anti‐inflammatory cytokines mediate the progression of severe anemia in malaria‐infected children: A prospective study

C Nkansah, F Osei‐Boakye, G Abbam… - Immunity …, 2024 - Wiley Online Library
Abstract Background Severe Plasmodium falciparum malarial anemia is still the principal
cause of death in children in underdeveloped countries. An imbalance between …

A distinct fingerprint of inflammatory mediators and miRNAs in Plasmodium vivax severe thrombocytopenia

MLS Santos, RS Coimbra, TN Sousa, LFF Guimarães… - bioRxiv, 2020 - biorxiv.org
Background Severe thrombocytopenia can be a determinant factor in the morbidity of
Plasmodium vivax (Pv), the most widespread human malaria. Although immune …

Human NCR3 gene variants rs2736191 and rs11575837 influence susceptibility to the longitudinal development of pediatric severe malarial anemia

O Onyango Clinton, Q Cheng, EO Munde, E Raballah… - 2022 - edocs.maseno.ac.ke
Plasmodium falciparum malaria is a leading cause of pediatric morbidity and mortality in
holoendemic transmission areas. Severe malarial anemia [SMA, hemoglobin (Hb)< 5.0 g/dL] …