RNA-targeting CRISPR–Cas systems
SPB van Beljouw, J Sanders… - Nature Reviews …, 2023 - nature.com
CRISPR–Cas is a widespread adaptive immune system in bacteria and archaea that
protects against viral infection by targeting specific invading nucleic acid sequences …
protects against viral infection by targeting specific invading nucleic acid sequences …
RNA-targeting CRISPR–Cas systems and their applications
M Burmistrz, K Krakowski… - International journal of …, 2020 - mdpi.com
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)–CRISPR-associated
(Cas) systems have revolutionized modern molecular biology. Numerous types of these …
(Cas) systems have revolutionized modern molecular biology. Numerous types of these …
SCOPE enables type III CRISPR-Cas diagnostics using flexible targeting and stringent CARF ribonuclease activation
Characteristic properties of type III CRISPR-Cas systems include recognition of target RNA
and the subsequent induction of a multifaceted immune response. This involves sequence …
and the subsequent induction of a multifaceted immune response. This involves sequence …
Coevolution between bacterial CRISPR-Cas systems and their bacteriophages
CRISPR-Cas systems provide bacteria and archaea with adaptive, heritable immunity
against their viruses (bacteriophages and phages) and other parasitic genetic elements …
against their viruses (bacteriophages and phages) and other parasitic genetic elements …
Specificity and sensitivity of an RNA targeting type III CRISPR complex coupled with a NucC endonuclease effector
S Grüschow, CS Adamson, MF White - Nucleic acids research, 2021 - academic.oup.com
Type III CRISPR systems detect invading RNA, resulting in the activation of the enzymatic
Cas10 subunit. The Cas10 cyclase domain generates cyclic oligoadenylate (cOA) second …
Cas10 subunit. The Cas10 cyclase domain generates cyclic oligoadenylate (cOA) second …
Control of cyclic oligoadenylate synthesis in a type III CRISPR system
The CRISPR system for prokaryotic adaptive immunity provides RNA-mediated protection
from viruses and mobile genetic elements. When viral RNA transcripts are detected, type III …
from viruses and mobile genetic elements. When viral RNA transcripts are detected, type III …
Anti-CRISPRs go viral: the infection biology of CRISPR-Cas inhibitors
Y Li, J Bondy-Denomy - Cell host & microbe, 2021 - cell.com
Bacteriophages encode diverse anti-CRISPR (Acr) proteins that inhibit CRISPR-Cas
immunity during infection of their bacterial hosts. Although detailed mechanisms have been …
immunity during infection of their bacterial hosts. Although detailed mechanisms have been …
Targeting of temperate phages drives loss of type I CRISPR–Cas systems
C Rollie, A Chevallereau, BNJ Watson, T Chyou… - Nature, 2020 - nature.com
On infection of their host, temperate viruses that infect bacteria (bacteriophages; hereafter
referred to as phages) enter either a lytic or a lysogenic cycle. The former results in lysis of …
referred to as phages) enter either a lytic or a lysogenic cycle. The former results in lysis of …
Evolutionary ecology and interplay of prokaryotic innate and adaptive immune systems
Like many organisms, bacteria and archaea have both innate and adaptive immune systems
to defend against infection by viruses and other parasites. Innate immunity most commonly …
to defend against infection by viruses and other parasites. Innate immunity most commonly …
It is unclear how important CRISPR-Cas systems are for protecting natural populations of bacteria against infections by mobile genetic elements
Articles on CRISPR commonly open with some variant of the phrase “these short
palindromic repeats and their associated endonucleases (Cas) are an adaptive immune …
palindromic repeats and their associated endonucleases (Cas) are an adaptive immune …