The new edition of the World Health Organization (WHO) book on 'Histological Typing of
Tumours of the Central Nervous System'reflects the progress in brain tumour classification …

One event that accompanies glioma progression is the upregulation of angiogenesis. Low‐
grade gliomas are moderately vascularized tumors whereas high‐grade gliomas show …

This book on the World Health Organization (WHO) classification of tumours of the nervous
system reflects the view of a working group that convened for an editorial and consensus …

The development and neoplastic progression of human astrocytic tumors appears to result
through an accumulation of genetic alterations occurring in a relatively defined order. One …

The molecular genetic alterations of oligodendroglial tumors and mixed gliomas of the
central nervous system were studied in a series of 37 cases (8 oligodendrogliomas, 13 …

Loss of cell cycle control and acquisition of chromosomal rearrangements such as gene
amplification often occur during tumor progression, suggesting that they may be correlated …

The availability of~ 53 knockout mice generated by gene targeting has enabled us to
investigate the functional role of the~ 53 tumor suppressor gene in initiation, promotion, and …

Cytogenetic and loss of heterozygosity studies have suggested the presence of at least one
tumor suppressor gene on chromosome 10 involved in the formation of high grade gliomas …

Allelic alterations of chromosomes 1 and 19 are frequent events in human diffuse gliomas
and have recently proven to be strong predictors of chemotherapeutic response and …

Mutations of the p53 tumor suppressor gene are a genetic hallmark of human astrocytic
neoplasms, but their predictive role in glioma progression is still poorly understood. We …