The Interleukin‐1 (IL‐1) superfamily cytokines and their single nucleotide polymorphisms (SNPs)

P Behzadi, AS Sameer, S Nissar… - Journal of …, 2022 - Wiley Online Library
Interleukins (ILs)—which are important members of cytokines—consist of a vast group of
molecules, including a wide range of immune mediators that contribute to the immunological …

Nuclear alarmin cytokines in inflammation

L Jiang, Y Shao, Y Tian, C Ouyang… - Journal of Immunology …, 2020 - Wiley Online Library
Pathogen‐associated molecular patterns (PAMPs) are some nonspecific and highly
conserved molecular structures of exogenous specific microbial pathogens, whose products …

Inherently Reduced Expression of ASC Restricts Caspase-1 Processing in Hepatocytes and Promotes Plasmodium Infection

C Marques-da-Silva, C Schmidt-Silva… - The Journal of …, 2024 - journals.aai.org
Inflammasome-mediated caspase-1 activation facilitates innate immune control of
Plasmodium in the liver, thereby limiting the incidence and severity of clinical malaria …

Exploring the role of IL-1β in inflammatory bowel disease pathogenesis

I Aggeletopoulou, M Kalafateli, EP Tsounis… - Frontiers in …, 2024 - frontiersin.org
Interleukin 1β (IL-1β) is a significant mediator of inflammation and tissue damage in IBD. The
balance between IL-1β and its endogenous inhibitor-IL-1Ra-, plays a critical role in both …

IL-1 family cytokines in inflammatory dermatoses: pathogenetic role and potential therapeutic implications

H Iznardo, L Puig - International Journal of Molecular Sciences, 2022 - mdpi.com
The interleukin-1 (IL-1) family is involved in the correct functioning and regulation of the
innate immune system, linking innate and adaptative immune responses. This complex …

The ST2/IL-33 pathway in adult and paediatric heart disease and transplantation

G Brunetti, B Barile, GP Nicchia, F Onorati, GB Luciani… - Biomedicines, 2023 - mdpi.com
ST2 is a member of interleukin 1 receptor family with soluble sST2 and transmembrane
ST2L isoforms. The ligand of ST2 is IL-33, which determines the activation of numerous …

Keratinocyte interleukin-36 receptor expression orchestrates psoriasiform inflammation in mice

YE Hernández-Santana, G Leon… - Life science …, 2020 - life-science-alliance.org
The IL-36 family cytokines have emerged as important mediators of dermal inflammation in
psoriasis and have been reported to provide a proinflammatory stimulus to a variety of …

Possible Roles of IL‐33 in the Innate‐Adaptive Immune Crosstalk of Psoriasis Pathogenesis

SP Cannavò, L Bertino, E Di Salvo… - Mediators of …, 2019 - Wiley Online Library
Background. IL‐33 belongs to the IL‐1 family, playing a role in several biologic processes as
well as in the pathogenesis of different diseases, including skin pathologies. It acts as an …

Dietary supplementation with Macleaya cordata extract alleviates intestinal injury in broiler chickens challenged with lipopolysaccharide by regulating gut microbiota …

X Wang, T Zhang, W Li, M Zhang, L Zhao… - Frontiers in …, 2024 - frontiersin.org
Introduction The prevention and mitigation of intestinal immune challenge is crucial for
poultry production. This study investigated the effects of dietary Macleaya cordata extract …

Inhibition of TBK1 by amlexanox attenuates paraquat-induced acute lung injury

N Wang, Y Li, X Wang, Z Ma, Y Wang, C Zhang… - Toxicology, 2020 - Elsevier
The specific mechanism of paraquat (PQ)-induced acute lung injury (ALI) is unclear, though
inflammation is a likely contributor. Amlexanox, a TANK binding kinase 1 (TBK1) inhibitor, is …