Dynamic alternative DNA structures in biology and disease
G Wang, KM Vasquez - Nature Reviews Genetics, 2023 - nature.com
Repetitive elements in the human genome, once considered 'junk DNA', are now known to
adopt more than a dozen alternative (that is, non-B) DNA structures, such as self-annealed …
adopt more than a dozen alternative (that is, non-B) DNA structures, such as self-annealed …
[HTML][HTML] Detection of alternative DNA structures and its implications for human disease
G Matos-Rodrigues, JA Hisey, A Nussenzweig… - Molecular Cell, 2023 - cell.com
Around 3% of the genome consists of simple DNA repeats that are prone to forming
alternative (non-B) DNA structures, such as hairpins, cruciforms, triplexes (H-DNA), four …
alternative (non-B) DNA structures, such as hairpins, cruciforms, triplexes (H-DNA), four …
Continuous synthesis of E. coli genome sections and Mb-scale human DNA assembly
Whole-genome synthesis provides a powerful approach for understanding and expanding
organism function,–. To build large genomes rapidly, scalably and in parallel, we need (1) …
organism function,–. To build large genomes rapidly, scalably and in parallel, we need (1) …
Radiotherapy is associated with a deletion signature that contributes to poor outcomes in patients with cancer
Ionizing radiation causes DNA damage and is a mainstay for cancer treatment, but
understanding of its genomic impact is limited. We analyzed mutational spectra following …
understanding of its genomic impact is limited. We analyzed mutational spectra following …
The chemotherapeutic drug CX-5461 is a potent mutagen in cultured human cells
GCC Koh, S Boushaki, SJ Zhao, AM Pregnall… - Nature Genetics, 2024 - nature.com
The chemotherapeutic agent CX-5461, or pidnarulex, has been fast-tracked by the United
States Food and Drug Administration for early-stage clinical studies of BRCA1-, BRCA2-and …
States Food and Drug Administration for early-stage clinical studies of BRCA1-, BRCA2-and …
Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism
Human papillomavirus (HPV) integration is a key genetic event in cervical carcinogenesis.
By conducting whole-genome sequencing and high-throughput viral integration detection …
By conducting whole-genome sequencing and high-throughput viral integration detection …
Non-B DNA: a major contributor to small-and large-scale variation in nucleotide substitution frequencies across the genome
Approximately 13% of the human genome can fold into non-canonical (non-B) DNA
structures (eg G-quadruplexes, Z-DNA, etc.), which have been implicated in vital cellular …
structures (eg G-quadruplexes, Z-DNA, etc.), which have been implicated in vital cellular …
Rate of elongation by RNA polymerase II is associated with specific gene features and epigenetic modifications
A Veloso, KS Kirkconnell, B Magnuson… - Genome …, 2014 - genome.cshlp.org
The rate of transcription elongation plays an important role in the timing of expression of full-
length transcripts as well as in the regulation of alternative splicing. In this study, we coupled …
length transcripts as well as in the regulation of alternative splicing. In this study, we coupled …
Non–B-form DNA tends to form in centromeric regions and has undergone changes in polyploid oat subgenomes
Q Liu, C Yi, Z Zhang, H Su, C Liu… - Proceedings of the …, 2023 - National Acad Sciences
Centromeres are the specialized regions of the chromosomes that direct faithful
chromosome segregation during cell division. Despite their functional conservation …
chromosome segregation during cell division. Despite their functional conservation …
The molecular landscape of ETMR at diagnosis and relapse
Embryonal tumours with multilayered rosettes (ETMRs) are aggressive paediatric embryonal
brain tumours with a universally poor prognosis. Here we collected 193 primary ETMRs and …
brain tumours with a universally poor prognosis. Here we collected 193 primary ETMRs and …