Prion diseases are progressive, incurable and fatal neurodegenerative conditions. The term
'prion'was first nominated to express the revolutionary concept that a protein could be …

Transmissible spongiform encephalopathies (TSEs) are inevitably lethal neurodegenerative
diseases that affect humans and a large variety of animals. The infectious agent responsible …

Stem cells persist throughout life by self-renewing in numerous tissues including the central
and peripheral nervous systems. This raises the issue of whether there is a conserved …

Chronic idiopathic thrombocytopenic purpura (ITP) is a bleeding disorder that is
characterized by increased platelet destruction and is believed to be autoantibody mediated …

Recent reports indicate that a growing number of intracellular proteins are not only prone to
pathological aggregation but can also be released and" infect" neighboring cells. Therefore …

Prions have been responsible for an entire century of tragic episodes. Fifty years ago, kuru
decimated the population of Papua New Guinea. Then, iatrogenic transmission of prions …

Parkinson's disease (PD) is a multisystem disorder with involvement of the peripheral
nervous system. Misfolding and aggregation of α‐synuclein is central to the pathogenesis of …

Prion diseases are infectious neurodegenerative diseases occurring in humans and animals
with an invariably lethal outcome. One fundamental mechanistic event in prion diseases is …

There is little doubt that the main component of the transmissible agent of spongiform
encephalopathies—the prion—is a conformational variant of the ubiquitous host protein …

Prion diseases are rapidly progressive, incurable neurodegenerative disorders caused by
misfolded, aggregated proteins known as prions, which are uniquely infectious. Remarkably …